Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors
Transarterial chemoembolization of the main vessels feeding the tumor is a minimally invasive procedure, which is intended to block off the blood supply to the tumor and to deliver a cytotoxic agent to tumor cells. Initially, this method was used in emergency cases, but later it gained the trust of...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-07-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/631 |
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| author | A. G. Kedrova D. P. Lebedev E. A. Zvezdkina D. A. Astakhov V. V. Kosyy R. V. Ishchenko |
| author_facet | A. G. Kedrova D. P. Lebedev E. A. Zvezdkina D. A. Astakhov V. V. Kosyy R. V. Ishchenko |
| author_sort | A. G. Kedrova |
| collection | DOAJ |
| description | Transarterial chemoembolization of the main vessels feeding the tumor is a minimally invasive procedure, which is intended to block off the blood supply to the tumor and to deliver a cytotoxic agent to tumor cells. Initially, this method was used in emergency cases, but later it gained the trust of clinicians, who began to use it in non-emergency patients with clinical manifestations, when angiography showed well-supplied tumors inaccessible for ablation or surgical removal, including those in non-standard difficult cases. Selective catheterization of dominant arteries in recurrent tumors along with chemoembolization with drug-eluting microspheres is extremely challenging, since most of recurrent tumors have a well-developed neovascular network. HepaSphere microspheres, due to their hydrophilicity and high biological compatibility with tissues, allow the deposition of a chemotherapeutic agent in the tumor. This therapy provides pronounced hemostatic and antitumor effects confirmed by morphological and immunohistochemical examination. Currently, transarterial chemoembolization is mainly used for primary tumors and becomes increasingly popular as an element of combination therapy for patients with pelvic tumors. In this article, we analyze clinical data for 14 patients with recurrent pelvic tumors who underwent chemoembolization with HepaSpheres loaded with doxorubicin or irinotecan as a part of their palliative care. |
| format | Article |
| id | doaj-art-f0d2b323dad34a4e9414d487bf05f2e9 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-f0d2b323dad34a4e9414d487bf05f2e92025-08-20T04:00:02ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272019-07-01151354110.17650/1994-4098-2019-15-1-35-41602Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumorsA. G. Kedrova0D. P. Lebedev1E. A. Zvezdkina2D. A. Astakhov3V. V. Kosyy4R. V. Ishchenko5Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation; Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian FederationFederal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian FederationFederal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian FederationFederal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian FederationFederal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian FederationFederal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation; Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian FederationTransarterial chemoembolization of the main vessels feeding the tumor is a minimally invasive procedure, which is intended to block off the blood supply to the tumor and to deliver a cytotoxic agent to tumor cells. Initially, this method was used in emergency cases, but later it gained the trust of clinicians, who began to use it in non-emergency patients with clinical manifestations, when angiography showed well-supplied tumors inaccessible for ablation or surgical removal, including those in non-standard difficult cases. Selective catheterization of dominant arteries in recurrent tumors along with chemoembolization with drug-eluting microspheres is extremely challenging, since most of recurrent tumors have a well-developed neovascular network. HepaSphere microspheres, due to their hydrophilicity and high biological compatibility with tissues, allow the deposition of a chemotherapeutic agent in the tumor. This therapy provides pronounced hemostatic and antitumor effects confirmed by morphological and immunohistochemical examination. Currently, transarterial chemoembolization is mainly used for primary tumors and becomes increasingly popular as an element of combination therapy for patients with pelvic tumors. In this article, we analyze clinical data for 14 patients with recurrent pelvic tumors who underwent chemoembolization with HepaSpheres loaded with doxorubicin or irinotecan as a part of their palliative care.https://ojrs.abvpress.ru/ojrs/article/view/631arterial chemoembolizationrecurrent pelvic tumorsbleeding from recurrent pelvic tumorshepasphere |
| spellingShingle | A. G. Kedrova D. P. Lebedev E. A. Zvezdkina D. A. Astakhov V. V. Kosyy R. V. Ishchenko Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors Опухоли женской репродуктивной системы arterial chemoembolization recurrent pelvic tumors bleeding from recurrent pelvic tumors hepasphere |
| title | Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors |
| title_full | Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors |
| title_fullStr | Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors |
| title_full_unstemmed | Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors |
| title_short | Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors |
| title_sort | chemoembolization with hepaspheres in the treatment of recurrent pelvic tumors |
| topic | arterial chemoembolization recurrent pelvic tumors bleeding from recurrent pelvic tumors hepasphere |
| url | https://ojrs.abvpress.ru/ojrs/article/view/631 |
| work_keys_str_mv | AT agkedrova chemoembolizationwithhepaspheresinthetreatmentofrecurrentpelvictumors AT dplebedev chemoembolizationwithhepaspheresinthetreatmentofrecurrentpelvictumors AT eazvezdkina chemoembolizationwithhepaspheresinthetreatmentofrecurrentpelvictumors AT daastakhov chemoembolizationwithhepaspheresinthetreatmentofrecurrentpelvictumors AT vvkosyy chemoembolizationwithhepaspheresinthetreatmentofrecurrentpelvictumors AT rvishchenko chemoembolizationwithhepaspheresinthetreatmentofrecurrentpelvictumors |