A ROLE OF SUPEROXIDE DISMUTASE IN DEVELOPMENT OF POST-OPERATION ATRIAL FIBRILLATION IN CORONARY HEART DISEASE PATIENTS
Aim. To evaluate the level of superoxide dismutase (SOD) in coronary heart disease (CHD) patients underwent coronary bypass (CBG), and to estimate its importance in development of post-surgery atrial fibrillation (PSAF).Material and methods. Totally, 96 patients studied, with CHD, admitted for CB...
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«FIRMA «SILICEA» LLC
2017-03-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1592 |
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| author | O. A. Rubanenko O. V. Fatenkov S. M. Khokhlunov L. V. Limareva |
| author_facet | O. A. Rubanenko O. V. Fatenkov S. M. Khokhlunov L. V. Limareva |
| author_sort | O. A. Rubanenko |
| collection | DOAJ |
| description | Aim. To evaluate the level of superoxide dismutase (SOD) in coronary heart disease (CHD) patients underwent coronary bypass (CBG), and to estimate its importance in development of post-surgery atrial fibrillation (PSAF).Material and methods. Totally, 96 patients studied, with CHD, admitted for CBG. Patients were selected to 2 groups: 1 group — non-PSAF (67 patients, 80,6% males, mean age 57,9±7,3 y.o.), 2 group — with first time AF in early period of CBG (29 patients, 86% males, mean age 64,0±8,4 y.o.).Results. During study period PSAF developed in 30,2% cases, mean on 4,9±3,8 day after surgery. Comparing with group 1, level of SOD was higher in group 2 patients (2589,8±1999,3 U/g vs 1572,8±1275,2 U/g, р=0,034). Patients of group 2 were older 4 years in average (64,0±8,4 vs 57,9±7,3 y., р=0,048), had longer duration of cardiovascular pathology (86,9±76,1 months vs 44,3±38,4 m., р=0,002). Patients with PSAF had III functional class of angina (72,4% vs 47,8%, р=0,028) and III functional class of congestive heart failure (38,0% vs 7,5%, р=0,006), they had larger left atrium (43,5±4,1 mm vs 37,9±3,4 mm, р<0,001).After multifactorial analysis, predictive value remained for the following: left atrium larger than 41 mm — 5,1 (95% CI, 2,1-9,8, р=0,0005), SOD more than 2948 U/g — 4,4 (95% CI, 1,1-8,9, р=0,04).Conclusion. The study showed that CBG operation is followed by activation of oxidation stress which is followed by the decrease of SOD concentration, probably due to its consumption. However, among patients with PSAF there is higher activity of this enzyme. |
| format | Article |
| id | doaj-art-f0c7bdfa2e374aaa91b46554f3455abd |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2017-03-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-f0c7bdfa2e374aaa91b46554f3455abd2025-08-20T03:57:26Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-03-0103202410.15829/1560-4071-2017-3-20-241375A ROLE OF SUPEROXIDE DISMUTASE IN DEVELOPMENT OF POST-OPERATION ATRIAL FIBRILLATION IN CORONARY HEART DISEASE PATIENTSO. A. Rubanenko0O. V. Fatenkov1S. M. Khokhlunov2L. V. Limareva3Samara State Medical University; Samara Regional Clinical Cardiological DispensarySamara State Medical UniversitySamara State Medical University; Samara Regional Clinical Cardiological DispensarySamara State Medical UniversityAim. To evaluate the level of superoxide dismutase (SOD) in coronary heart disease (CHD) patients underwent coronary bypass (CBG), and to estimate its importance in development of post-surgery atrial fibrillation (PSAF).Material and methods. Totally, 96 patients studied, with CHD, admitted for CBG. Patients were selected to 2 groups: 1 group — non-PSAF (67 patients, 80,6% males, mean age 57,9±7,3 y.o.), 2 group — with first time AF in early period of CBG (29 patients, 86% males, mean age 64,0±8,4 y.o.).Results. During study period PSAF developed in 30,2% cases, mean on 4,9±3,8 day after surgery. Comparing with group 1, level of SOD was higher in group 2 patients (2589,8±1999,3 U/g vs 1572,8±1275,2 U/g, р=0,034). Patients of group 2 were older 4 years in average (64,0±8,4 vs 57,9±7,3 y., р=0,048), had longer duration of cardiovascular pathology (86,9±76,1 months vs 44,3±38,4 m., р=0,002). Patients with PSAF had III functional class of angina (72,4% vs 47,8%, р=0,028) and III functional class of congestive heart failure (38,0% vs 7,5%, р=0,006), they had larger left atrium (43,5±4,1 mm vs 37,9±3,4 mm, р<0,001).After multifactorial analysis, predictive value remained for the following: left atrium larger than 41 mm — 5,1 (95% CI, 2,1-9,8, р=0,0005), SOD more than 2948 U/g — 4,4 (95% CI, 1,1-8,9, р=0,04).Conclusion. The study showed that CBG operation is followed by activation of oxidation stress which is followed by the decrease of SOD concentration, probably due to its consumption. However, among patients with PSAF there is higher activity of this enzyme.https://russjcardiol.elpub.ru/jour/article/view/1592atrial fibrillationcoronary bypasssuperoxide dismutase |
| spellingShingle | O. A. Rubanenko O. V. Fatenkov S. M. Khokhlunov L. V. Limareva A ROLE OF SUPEROXIDE DISMUTASE IN DEVELOPMENT OF POST-OPERATION ATRIAL FIBRILLATION IN CORONARY HEART DISEASE PATIENTS Российский кардиологический журнал atrial fibrillation coronary bypass superoxide dismutase |
| title | A ROLE OF SUPEROXIDE DISMUTASE IN DEVELOPMENT OF POST-OPERATION ATRIAL FIBRILLATION IN CORONARY HEART DISEASE PATIENTS |
| title_full | A ROLE OF SUPEROXIDE DISMUTASE IN DEVELOPMENT OF POST-OPERATION ATRIAL FIBRILLATION IN CORONARY HEART DISEASE PATIENTS |
| title_fullStr | A ROLE OF SUPEROXIDE DISMUTASE IN DEVELOPMENT OF POST-OPERATION ATRIAL FIBRILLATION IN CORONARY HEART DISEASE PATIENTS |
| title_full_unstemmed | A ROLE OF SUPEROXIDE DISMUTASE IN DEVELOPMENT OF POST-OPERATION ATRIAL FIBRILLATION IN CORONARY HEART DISEASE PATIENTS |
| title_short | A ROLE OF SUPEROXIDE DISMUTASE IN DEVELOPMENT OF POST-OPERATION ATRIAL FIBRILLATION IN CORONARY HEART DISEASE PATIENTS |
| title_sort | role of superoxide dismutase in development of post operation atrial fibrillation in coronary heart disease patients |
| topic | atrial fibrillation coronary bypass superoxide dismutase |
| url | https://russjcardiol.elpub.ru/jour/article/view/1592 |
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