Differential Expression of Intestinal Genes in Opossums with High and Low Responses to Dietary Cholesterol
High and low responding opossums (Monodelphis domestica) differ in their plasma very low density lipoprotein and low density lipoprotein (VLDL+LDL) cholesterol concentrations when they consume a high...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2010/415075 |
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| Summary: | High and low
responding opossums (Monodelphis
domestica) differ in their plasma very
low density lipoprotein and low density
lipoprotein (VLDL+LDL) cholesterol
concentrations when they consume a high
cholesterol diet, which is due in part to
absorption of a higher percentage of dietary
cholesterol in high responders. We compared the
expression of a set of genes that influence
cholesterol absorption in high and low
responders fed a basal or a high cholesterol and
low fat (HCLF) diet. Up-regulation of the
ABCG5, ABCG8,
and IBABP genes by the HCLF
diet in high and low responders may reduce
cholesterol absorption to maintain cholesterol
homeostasis. Differences in expression of the
phospholipase genes (PLA2 and
PLB) and phospholipase activity
were associated with differences in cholesterol
absorption when opossums were fed
cholesterol-enriched diets. Higher
PLA2 and PLB
mRNA levels and higher phospholipase activity
may increase cholesterol absorption in high
responders by enhancing the release of
cholesterol from bile salt micelles for uptake
by intestinal cells. |
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| ISSN: | 2090-0724 2090-0732 |