Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease

Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease

ContextShenyuan Granules (SYG), a traditional Chinese medicine preparation, are clinically used for treating chronic kidney diseases. However, the role of Klotho in modulating cellular senescence via the p16/p21 pathway and its involvement in the therapeutic effects of SYG in diabetic kidney disease...

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Bibliographic Details
Main Authors:	Xinyuan Guo, Siyang Zhang, Qingqing Sun, Huimeng Li, Lan Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Medicine
Subjects:	traditional Chinese medicine Shenyuan granules cellular senescence Klotho p16 p21
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1627412/full
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