Stability and neurotoxic impact of organophosphate pesticides in aqueous environments
Introduction/purpose: Organophosphates are widely used nowadays. They have applications as pesticides, drugs, plasticizers, flame retardants, or chemical warfare agents. Their acute toxicity is ascribed to inhibiting acetylcholinesterase (AChE), a key enzyme in the transmission of nerve impulses in...
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University of Defence in Belgrade
2025-01-01
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| Series: | Vojnotehnički Glasnik |
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| Online Access: | https://scindeks.ceon.rs/article.aspx?artid=0042-84692501264A |
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| author | Vladan J. Anićijević Tamara Tasić Vedran Milanković Radovan M. Karkalić Tamara D. Lazarević Pašti |
| author_facet | Vladan J. Anićijević Tamara Tasić Vedran Milanković Radovan M. Karkalić Tamara D. Lazarević Pašti |
| author_sort | Vladan J. Anićijević |
| collection | DOAJ |
| description | Introduction/purpose: Organophosphates are widely used nowadays. They have applications as pesticides, drugs, plasticizers, flame retardants, or chemical warfare agents. Their acute toxicity is ascribed to inhibiting acetylcholinesterase (AChE), a key enzyme in the transmission of nerve impulses in animals. Their toxic effects manifest by acetylcholine accumulation in the nerve synapses and can lead to paralysis or death. Organo-thiophosphate pesticides (OPs) are used in large quantities. Their oxo-analogs can also be found in the environment due to oxidation. Once accumulated in the environment, they exhibit toxic effects on non-target organisms. Methods: The hydrolysis of OPs in different pH was systematically analyzed, and their neurotoxic effects were evaluated. The concentration of the investigated pesticides during decomposition was monitored by ultraperformance liquid chromatography (UPLC). At the same time, a decrease in the toxicity of the treated samples was observed by measuring the activity of the enzyme AChE. Results: OPs decompose rapidly in alkaline aqueous solutions but are highly stable in acidic solutions. Chlorpyrifos hydrolyzes the fastest and dimethoate the slowest. The toxicity of these OP solutions decreases over time, indicating that more toxic products were not formed. Conclusion: The presented results can provide a sound basis for further efforts to find simple and efficient decomposition methods of OPs. |
| format | Article |
| id | doaj-art-f0b967acf04d46d0a002e20f33f7b33e |
| institution | Kabale University |
| issn | 0042-8469 2217-4753 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Defence in Belgrade |
| record_format | Article |
| series | Vojnotehnički Glasnik |
| spelling | doaj-art-f0b967acf04d46d0a002e20f33f7b33e2025-02-07T11:37:30ZengUniversity of Defence in BelgradeVojnotehnički Glasnik0042-84692217-47532025-01-0173126428110.5937/vojtehg73-53901Stability and neurotoxic impact of organophosphate pesticides in aqueous environmentsVladan J. Anićijević0https://orcid.org/0000-0001-8731-1378Tamara Tasić1https://orcid.org/0000-0003-1988-4064Vedran Milanković2https://orcid.org/0000-0002-7706-9036Radovan M. Karkalić3https://orcid.org/0000-0002-8074-7264Tamara D. Lazarević Pašti4https://orcid.org/0000-0001-6220-2079University of Defence in Belgrade, Military Academy, Belgrade, Republic of SerbiaUniversity of Belgrade, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Belgrade, Republic of SerbiaUniversity of Belgrade, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Belgrade, Republic of SerbiaUniversity of Defence in Belgrade, Military Academy, Belgrade, Republic of SerbiaUniversity of Belgrade, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Belgrade, Republic of SerbiaIntroduction/purpose: Organophosphates are widely used nowadays. They have applications as pesticides, drugs, plasticizers, flame retardants, or chemical warfare agents. Their acute toxicity is ascribed to inhibiting acetylcholinesterase (AChE), a key enzyme in the transmission of nerve impulses in animals. Their toxic effects manifest by acetylcholine accumulation in the nerve synapses and can lead to paralysis or death. Organo-thiophosphate pesticides (OPs) are used in large quantities. Their oxo-analogs can also be found in the environment due to oxidation. Once accumulated in the environment, they exhibit toxic effects on non-target organisms. Methods: The hydrolysis of OPs in different pH was systematically analyzed, and their neurotoxic effects were evaluated. The concentration of the investigated pesticides during decomposition was monitored by ultraperformance liquid chromatography (UPLC). At the same time, a decrease in the toxicity of the treated samples was observed by measuring the activity of the enzyme AChE. Results: OPs decompose rapidly in alkaline aqueous solutions but are highly stable in acidic solutions. Chlorpyrifos hydrolyzes the fastest and dimethoate the slowest. The toxicity of these OP solutions decreases over time, indicating that more toxic products were not formed. Conclusion: The presented results can provide a sound basis for further efforts to find simple and efficient decomposition methods of OPs.https://scindeks.ceon.rs/article.aspx?artid=0042-84692501264Aorganophosphatepesticideph stabilitytoxicity |
| spellingShingle | Vladan J. Anićijević Tamara Tasić Vedran Milanković Radovan M. Karkalić Tamara D. Lazarević Pašti Stability and neurotoxic impact of organophosphate pesticides in aqueous environments Vojnotehnički Glasnik organophosphate pesticide ph stability toxicity |
| title | Stability and neurotoxic impact of organophosphate pesticides in aqueous environments |
| title_full | Stability and neurotoxic impact of organophosphate pesticides in aqueous environments |
| title_fullStr | Stability and neurotoxic impact of organophosphate pesticides in aqueous environments |
| title_full_unstemmed | Stability and neurotoxic impact of organophosphate pesticides in aqueous environments |
| title_short | Stability and neurotoxic impact of organophosphate pesticides in aqueous environments |
| title_sort | stability and neurotoxic impact of organophosphate pesticides in aqueous environments |
| topic | organophosphate pesticide ph stability toxicity |
| url | https://scindeks.ceon.rs/article.aspx?artid=0042-84692501264A |
| work_keys_str_mv | AT vladanjanicijevic stabilityandneurotoxicimpactoforganophosphatepesticidesinaqueousenvironments AT tamaratasic stabilityandneurotoxicimpactoforganophosphatepesticidesinaqueousenvironments AT vedranmilankovic stabilityandneurotoxicimpactoforganophosphatepesticidesinaqueousenvironments AT radovanmkarkalic stabilityandneurotoxicimpactoforganophosphatepesticidesinaqueousenvironments AT tamaradlazarevicpasti stabilityandneurotoxicimpactoforganophosphatepesticidesinaqueousenvironments |