Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol
Painful conditions of the pelvic floor include a set of disorders of the pelvic region, discreetly prevalent in the female population, in which pain emerges as the predominant symptom. Such disorders have a significant impact on quality of life as they impair couple relationships and promote states...
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| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/12/1627 |
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| author | Roberto Bonanni Patrizia Ratano Ida Cariati Virginia Tancredi Pierangelo Cifelli |
| author_facet | Roberto Bonanni Patrizia Ratano Ida Cariati Virginia Tancredi Pierangelo Cifelli |
| author_sort | Roberto Bonanni |
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| description | Painful conditions of the pelvic floor include a set of disorders of the pelvic region, discreetly prevalent in the female population, in which pain emerges as the predominant symptom. Such disorders have a significant impact on quality of life as they impair couple relationships and promote states of anxiety and irascibility in affected individuals. Although numerous treatment approaches have been proposed for the management of such disorders, there is a need to identify strategies to promote muscle relaxation, counter pelvic pain, and reduce inflammation. The endocannabinoid system (ECS) represents a complex system spread throughout the body and is involved in the regulation of numerous physiological processes representing a potential therapeutic target for mood and anxiety disorders as well as pain management. Cannabidiol (CBD), acting on the ECS, can promote relief from hyperalgesia and allodynia typical of disorders affecting the pelvic floor and promote muscle relaxation by restoring balance to this delicate anatomical region. However, its use is currently limited due to a lack of evidence supporting its efficacy and harmlessness, and the mechanism of action on the ECS remains partially unexplored to this day. This comprehensive review of the literature examines the impact of pain disorders affecting the pelvic floor and major treatment approaches and brings together the main evidence supporting CBD in the management of such disorders. |
| format | Article |
| id | doaj-art-f0b65df6aedf46bcada8dbf49743eae8 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-f0b65df6aedf46bcada8dbf49743eae82025-08-20T02:01:00ZengMDPI AGBiomolecules2218-273X2024-12-011412162710.3390/biom14121627Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of CannabidiolRoberto Bonanni0Patrizia Ratano1Ida Cariati2Virginia Tancredi3Pierangelo Cifelli4Department of Biomedicine and Prevention, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità (ISS), 00161 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Applied Clinical and Biotechnological Sciences, University of L’Aquila, 67100 L’Aquila, ItalyPainful conditions of the pelvic floor include a set of disorders of the pelvic region, discreetly prevalent in the female population, in which pain emerges as the predominant symptom. Such disorders have a significant impact on quality of life as they impair couple relationships and promote states of anxiety and irascibility in affected individuals. Although numerous treatment approaches have been proposed for the management of such disorders, there is a need to identify strategies to promote muscle relaxation, counter pelvic pain, and reduce inflammation. The endocannabinoid system (ECS) represents a complex system spread throughout the body and is involved in the regulation of numerous physiological processes representing a potential therapeutic target for mood and anxiety disorders as well as pain management. Cannabidiol (CBD), acting on the ECS, can promote relief from hyperalgesia and allodynia typical of disorders affecting the pelvic floor and promote muscle relaxation by restoring balance to this delicate anatomical region. However, its use is currently limited due to a lack of evidence supporting its efficacy and harmlessness, and the mechanism of action on the ECS remains partially unexplored to this day. This comprehensive review of the literature examines the impact of pain disorders affecting the pelvic floor and major treatment approaches and brings together the main evidence supporting CBD in the management of such disorders.https://www.mdpi.com/2218-273X/14/12/1627pelvic floor conditionscannabidiolendocannabinoid systemcannabinoid receptorsphysiologypelvic pain |
| spellingShingle | Roberto Bonanni Patrizia Ratano Ida Cariati Virginia Tancredi Pierangelo Cifelli Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol Biomolecules pelvic floor conditions cannabidiol endocannabinoid system cannabinoid receptors physiology pelvic pain |
| title | Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol |
| title_full | Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol |
| title_fullStr | Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol |
| title_full_unstemmed | Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol |
| title_short | Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol |
| title_sort | treatment strategies for painful pelvic floor conditions a focus on the potential benefits of cannabidiol |
| topic | pelvic floor conditions cannabidiol endocannabinoid system cannabinoid receptors physiology pelvic pain |
| url | https://www.mdpi.com/2218-273X/14/12/1627 |
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