Xanthine oxidase inhibitory activity of Arcangelisia flava
Background: Hyperuricemia is characterized by elevated levels of uric acid in the blood, produced from its precursor's xanthine and hypoxanthine via xanthine oxidase. Arcangelisia flava, an herbal medicine containing flavonoids, may decrease uric acid levels by inhibiting the xanthine oxidase....
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| Format: | Article |
| Language: | English |
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Indonesian Society for Biochemistry and Molecular Biology
2022-11-01
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| Series: | Acta Biochimica Indonesiana |
| Subjects: | |
| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/71 |
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| _version_ | 1825199621392039936 |
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| author | Fatmawati Subandrate Safyudin Medina Athiah M Fitra Romadhon Aulia Firdha Tariza |
| author_facet | Fatmawati Subandrate Safyudin Medina Athiah M Fitra Romadhon Aulia Firdha Tariza |
| author_sort | Fatmawati |
| collection | DOAJ |
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Background: Hyperuricemia is characterized by elevated levels of uric acid in the blood, produced from its precursor's xanthine and hypoxanthine via xanthine oxidase. Arcangelisia flava, an herbal medicine containing flavonoids, may decrease uric acid levels by inhibiting the xanthine oxidase.
Objective: This study was to determine the effectiveness of ethanol extracts of A. flava leaves and stems in inhibiting xanthine oxidase.
Methods: The leaves and stems of A. flava were extracted using ethanol 96%. Xanthine oxidase activity was measured using UV Vis spectrophotometry and represented as IC50 value. Allopurinol was used as a positive control.
Results: The IC50 value of xanthine oxidase inhibitory of ethanol extract of A. flava leaves and stems as well as allopurinol was 174.62, 30.44, 24.03 ppm.
Conclusion: The stems of A. flava have the activity of lowering uric acid levels better than the leaves.
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| format | Article |
| id | doaj-art-f0b019e8e51d468f822db3319b5f5f28 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-f0b019e8e51d468f822db3319b5f5f282025-02-08T03:06:01ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222022-11-015110.32889/actabioina.71Xanthine oxidase inhibitory activity of Arcangelisia flavaFatmawati0Subandrate1Safyudin2Medina Athiah3M Fitra Romadhon4Aulia Firdha Tariza5Faculty of Medicine, Universitas Sriwijaya, Palembang 30128, IndonesiaFaculty of Medicine, Universitas Sriwijaya, Palembang 30128, IndonesiaFaculty of Medicine, Universitas Sriwijaya, Palembang 30128, IndonesiaFaculty of Medicine, Universitas Sriwijaya, Palembang 30128, IndonesiaFaculty of Medicine, Universitas Sriwijaya, Palembang 30128, IndonesiaFaculty of Medicine, Universitas Sriwijaya, Palembang 30128, Indonesia Background: Hyperuricemia is characterized by elevated levels of uric acid in the blood, produced from its precursor's xanthine and hypoxanthine via xanthine oxidase. Arcangelisia flava, an herbal medicine containing flavonoids, may decrease uric acid levels by inhibiting the xanthine oxidase. Objective: This study was to determine the effectiveness of ethanol extracts of A. flava leaves and stems in inhibiting xanthine oxidase. Methods: The leaves and stems of A. flava were extracted using ethanol 96%. Xanthine oxidase activity was measured using UV Vis spectrophotometry and represented as IC50 value. Allopurinol was used as a positive control. Results: The IC50 value of xanthine oxidase inhibitory of ethanol extract of A. flava leaves and stems as well as allopurinol was 174.62, 30.44, 24.03 ppm. Conclusion: The stems of A. flava have the activity of lowering uric acid levels better than the leaves. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/71Arcangelisia flavaxanthine oxidasehyperuricemiauric acid |
| spellingShingle | Fatmawati Subandrate Safyudin Medina Athiah M Fitra Romadhon Aulia Firdha Tariza Xanthine oxidase inhibitory activity of Arcangelisia flava Acta Biochimica Indonesiana Arcangelisia flava xanthine oxidase hyperuricemia uric acid |
| title | Xanthine oxidase inhibitory activity of Arcangelisia flava |
| title_full | Xanthine oxidase inhibitory activity of Arcangelisia flava |
| title_fullStr | Xanthine oxidase inhibitory activity of Arcangelisia flava |
| title_full_unstemmed | Xanthine oxidase inhibitory activity of Arcangelisia flava |
| title_short | Xanthine oxidase inhibitory activity of Arcangelisia flava |
| title_sort | xanthine oxidase inhibitory activity of arcangelisia flava |
| topic | Arcangelisia flava xanthine oxidase hyperuricemia uric acid |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/71 |
| work_keys_str_mv | AT fatmawati xanthineoxidaseinhibitoryactivityofarcangelisiaflava AT subandrate xanthineoxidaseinhibitoryactivityofarcangelisiaflava AT safyudin xanthineoxidaseinhibitoryactivityofarcangelisiaflava AT medinaathiah xanthineoxidaseinhibitoryactivityofarcangelisiaflava AT mfitraromadhon xanthineoxidaseinhibitoryactivityofarcangelisiaflava AT auliafirdhatariza xanthineoxidaseinhibitoryactivityofarcangelisiaflava |