Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two Cases
Cytomegalovirus (CMV) infection is a common cause of morbidity and mortality in immunocompromised hosts. Tissue-invasive CMV disease causing ulcerative skin disease or esophageal necrosis is rare. We herein describe two cases: a 47-year-old renal and pancreas transplant recipient who presented with...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2017/4916973 |
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| author | Alfredo Mena Lora Justin Khine Nadia Khosrodad Vijay Yeldandi |
| author_facet | Alfredo Mena Lora Justin Khine Nadia Khosrodad Vijay Yeldandi |
| author_sort | Alfredo Mena Lora |
| collection | DOAJ |
| description | Cytomegalovirus (CMV) infection is a common cause of morbidity and mortality in immunocompromised hosts. Tissue-invasive CMV disease causing ulcerative skin disease or esophageal necrosis is rare. We herein describe two cases: a 47-year-old renal and pancreas transplant recipient who presented with skin ulcerations on his elbow and a 50-year-old renal transplant recipient who presented with acute esophageal necrosis. In both, tissue biopsy revealed CMV inclusion bodies by immunohistochemical staining of infected endothelial and mucosal cells. Ganciclovir was given to both cases and full remission occurred. Due to the varying presentations of acute CMV infection in immunosuppressed hosts, high suspicion and early tissue biopsy are vital for proper diagnosis and treatment when any suspicious cutaneous or mucosal manifestations are present. |
| format | Article |
| id | doaj-art-f0abe46e0d02405cb086d43710046043 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-f0abe46e0d02405cb086d437100460432025-02-03T07:23:52ZengWileyCase Reports in Transplantation2090-69432090-69512017-01-01201710.1155/2017/49169734916973Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two CasesAlfredo Mena Lora0Justin Khine1Nadia Khosrodad2Vijay Yeldandi3Division of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USASchool of Medicine, Ross University, Miramar, FL, USASchool of Medicine, Ross University, Miramar, FL, USADivision of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USACytomegalovirus (CMV) infection is a common cause of morbidity and mortality in immunocompromised hosts. Tissue-invasive CMV disease causing ulcerative skin disease or esophageal necrosis is rare. We herein describe two cases: a 47-year-old renal and pancreas transplant recipient who presented with skin ulcerations on his elbow and a 50-year-old renal transplant recipient who presented with acute esophageal necrosis. In both, tissue biopsy revealed CMV inclusion bodies by immunohistochemical staining of infected endothelial and mucosal cells. Ganciclovir was given to both cases and full remission occurred. Due to the varying presentations of acute CMV infection in immunosuppressed hosts, high suspicion and early tissue biopsy are vital for proper diagnosis and treatment when any suspicious cutaneous or mucosal manifestations are present.http://dx.doi.org/10.1155/2017/4916973 |
| spellingShingle | Alfredo Mena Lora Justin Khine Nadia Khosrodad Vijay Yeldandi Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two Cases Case Reports in Transplantation |
| title | Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two Cases |
| title_full | Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two Cases |
| title_fullStr | Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two Cases |
| title_full_unstemmed | Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two Cases |
| title_short | Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two Cases |
| title_sort | unusual manifestations of acute cytomegalovirus infection in solid organ transplant hosts a report of two cases |
| url | http://dx.doi.org/10.1155/2017/4916973 |
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