Assessment of early response to neoadjuvant chemotherapy in multi-site high-grade serous ovarian cancer using hyperpolarized-13C MRI

Assessment of early response to neoadjuvant chemotherapy in multi-site high-grade serous ovarian cancer using hyperpolarized-13C MRI

Abstract Background To evaluate the capability of hyperpolarized [1-13C] pyruvate MRI to predict pathologic response to neoadjuvant treatment in multi-site abdominopelvic disease of high-grade serous ovarian cancer (HGSOC) patients and to compare 13C MRI and [18F]-FDG PET/CT measurements for detecti...

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Main Authors: Lucian Beer, Vlad Bura, Stephan Ursprung, Ramona Woitek, Mary A. McLean, Joo Ern Ang, Mercedes Jimenez-Linan, Andrew B. Gill, Joshua Kaggie, Matthew Locke, Amy Frary, Johanna Field-Rayner, Ilse Patterson, Marika Reinius, Martin J. Graves, Surrin Deen, Gabriel Funingana, Leonardo Rundo, Andrew Priest, Luigi Aloj, Roido Manavaki, Iosif A. Mendichovszky, Fraser Robb, Rolf F. Schulte, Dominique-Laurent Couturier, Clive S. D’Santos, Valar Franklin, Kamal Kishore, Iris Allajbeu, Carolin Sauer, Ferdia A. Gallagher, Kevin M. Brindle, James D. Brenton, Evis Sala
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:EJNMMI Research
Subjects:
Ovarian cancer
Hyperpolarized MRI
Functional imaging
Hybrid imaging
Oncologic imaging
Online Access:https://doi.org/10.1186/s13550-025-01219-5
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