Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease 1-4:Meta-analysis
Objective To evaluate the efficacy of uric acid lowering therapy in delaying the progression of chronic kidney disease（CKD）and the incidence of adverse events.Methods The databases of PubMed, Embase, Web of Science, Cochrane Library, CNKI,WanFang and VIP were searched for screening, evaluating and e...
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | Yin Ri-ping Fan Zhen-liang Yang Meng-fan Song Li-qun |
| author_facet | Yin Ri-ping Fan Zhen-liang Yang Meng-fan Song Li-qun |
| author_sort | Yin Ri-ping |
| collection | DOAJ |
| description | Objective To evaluate the efficacy of uric acid lowering therapy in delaying the progression of chronic kidney disease（CKD）and the incidence of adverse events.Methods The databases of PubMed, Embase, Web of Science, Cochrane Library, CNKI,WanFang and VIP were searched for screening, evaluating and extracting the relevant data from all eligible cohorts and randomized controlled studies on uric acid-lowering therapy for delayed progression of CKD.Finally random effect model or fixed effect model was utilized for summarizing the extracted data.Results Forty-six studies were eventually included（4,947 participants）.Among 37 studies（3,802 participants）,significant differences existed in serum uric acid changes[WMD-160.79,95%CI（-180.93,-140.65）,P<0.001].Combined analysis of 31 studies（3,794 participants）showed significant differences in the changes of estimated glomerular filtration rate（eGFR）[WMD4.62,95%CI（3.33,5.91）,P<0.001]and changes of serum creatinine（Scr）in 23 studies（2,026 participants）showed significant differences[WMD-30.13,95%CI（-37.56,-22.69）,P<0.001].Although uric acid lowering therapy could lower the incidence of renal adverse events in patients with CKD 1-4,it offered no marked benefits in terms of reducing cardiovascular events and all-cause mortality.Conclusion Uric acid lowering therapy can improve glomerular filtration rate and delay the progression of CKD 1-4.However, this protective effect may be influenced by multiple factors.Whether or not uric acid lowering therapy is necessary in clinical practices require specific analysis. |
| format | Article |
| id | doaj-art-f0a0d01ba4844e1bb13ec6b83cd0d4da |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-f0a0d01ba4844e1bb13ec6b83cd0d4da2025-08-20T02:28:54ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-0182683757901756Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease 1-4:Meta-analysisYin Ri-pingFan Zhen-liangYang Meng-fanSong Li-qunObjective To evaluate the efficacy of uric acid lowering therapy in delaying the progression of chronic kidney disease（CKD）and the incidence of adverse events.Methods The databases of PubMed, Embase, Web of Science, Cochrane Library, CNKI,WanFang and VIP were searched for screening, evaluating and extracting the relevant data from all eligible cohorts and randomized controlled studies on uric acid-lowering therapy for delayed progression of CKD.Finally random effect model or fixed effect model was utilized for summarizing the extracted data.Results Forty-six studies were eventually included（4,947 participants）.Among 37 studies（3,802 participants）,significant differences existed in serum uric acid changes[WMD-160.79,95%CI（-180.93,-140.65）,P<0.001].Combined analysis of 31 studies（3,794 participants）showed significant differences in the changes of estimated glomerular filtration rate（eGFR）[WMD4.62,95%CI（3.33,5.91）,P<0.001]and changes of serum creatinine（Scr）in 23 studies（2,026 participants）showed significant differences[WMD-30.13,95%CI（-37.56,-22.69）,P<0.001].Although uric acid lowering therapy could lower the incidence of renal adverse events in patients with CKD 1-4,it offered no marked benefits in terms of reducing cardiovascular events and all-cause mortality.Conclusion Uric acid lowering therapy can improve glomerular filtration rate and delay the progression of CKD 1-4.However, this protective effect may be influenced by multiple factors.Whether or not uric acid lowering therapy is necessary in clinical practices require specific analysis.http://www.lcszb.com/thesisDetails?columnId=57901756&Fpath=home&index=0HyperuricemiaUric acidChronic kidney disease |
| spellingShingle | Yin Ri-ping Fan Zhen-liang Yang Meng-fan Song Li-qun Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease 1-4:Meta-analysis Linchuang shenzangbing zazhi Hyperuricemia Uric acid Chronic kidney disease |
| title | Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease 1-4:Meta-analysis |
| title_full | Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease 1-4:Meta-analysis |
| title_fullStr | Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease 1-4:Meta-analysis |
| title_full_unstemmed | Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease 1-4:Meta-analysis |
| title_short | Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease 1-4:Meta-analysis |
| title_sort | effect of uric acid lowering therapy on renal function in patients with chronic kidney disease 1 4 meta analysis |
| topic | Hyperuricemia Uric acid Chronic kidney disease |
| url | http://www.lcszb.com/thesisDetails?columnId=57901756&Fpath=home&index=0 |
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