Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP
This study explores the effect of baclofen on the malignant phenotype of glioblastoma (GBM) and the growth of xenograft tumors and investigates the related mechanisms, aiming to reveal the effect of baclofen on the occurrence and development of GBM. The development of new therapeutic drugs for GBM l...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/2753571 |
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| _version_ | 1849690070946152448 |
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| author | Lin Zhu Juan Lu Zhijun Bao Shiwen Guo |
| author_facet | Lin Zhu Juan Lu Zhijun Bao Shiwen Guo |
| author_sort | Lin Zhu |
| collection | DOAJ |
| description | This study explores the effect of baclofen on the malignant phenotype of glioblastoma (GBM) and the growth of xenograft tumors and investigates the related mechanisms, aiming to reveal the effect of baclofen on the occurrence and development of GBM. The development of new therapeutic drugs for GBM lays a theoretical and experimental foundation. Research results show that baclofen could inhibit GBM cell proliferation and migration and promote GBM cell apoptosis; baclofen dose- and time-dependently could induce GBM cell YAP phosphorylation. YAP participated in the effect of baclofen on GBM cell proliferation and migration inhibition. Baclofen induced YAP phosphorylation in GBM cells through the GABABR2-Gs-Lats1/2 signaling pathway. Baclofen could inhibit the expression of survivin and Bcl2. Baclofen inhibits subcutaneous tumors by inducing YAP phosphorylation in vivo. |
| format | Article |
| id | doaj-art-f09d0ca3e6d649fcbb36dc94d986d895 |
| institution | DOAJ |
| issn | 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-f09d0ca3e6d649fcbb36dc94d986d8952025-08-20T03:21:26ZengWileyJournal of Chemistry2090-90712021-01-01202110.1155/2021/2753571Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAPLin Zhu0Juan Lu1Zhijun Bao2Shiwen Guo3Department of NeurosurgerySchool of Foreign StudiesDepartment of NeurosurgeryDepartment of NeurosurgeryThis study explores the effect of baclofen on the malignant phenotype of glioblastoma (GBM) and the growth of xenograft tumors and investigates the related mechanisms, aiming to reveal the effect of baclofen on the occurrence and development of GBM. The development of new therapeutic drugs for GBM lays a theoretical and experimental foundation. Research results show that baclofen could inhibit GBM cell proliferation and migration and promote GBM cell apoptosis; baclofen dose- and time-dependently could induce GBM cell YAP phosphorylation. YAP participated in the effect of baclofen on GBM cell proliferation and migration inhibition. Baclofen induced YAP phosphorylation in GBM cells through the GABABR2-Gs-Lats1/2 signaling pathway. Baclofen could inhibit the expression of survivin and Bcl2. Baclofen inhibits subcutaneous tumors by inducing YAP phosphorylation in vivo.http://dx.doi.org/10.1155/2021/2753571 |
| spellingShingle | Lin Zhu Juan Lu Zhijun Bao Shiwen Guo Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP Journal of Chemistry |
| title | Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP |
| title_full | Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP |
| title_fullStr | Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP |
| title_full_unstemmed | Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP |
| title_short | Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP |
| title_sort | mechanism of baclofen inhibiting the proliferation and metastasis of gbm by regulating yap |
| url | http://dx.doi.org/10.1155/2021/2753571 |
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