The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study
Abstract Objectives To investigate the causal relationship between the genetically predicted eosinophil counts and hepatocellular carcinoma (HCC) in East Asians. Additionally, we aimed to explore the infiltration and clinical impact of eosinophils in HCC using the Gene Expression Profiling Interacti...
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| Format: | Article |
| Language: | English |
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Springer
2025-03-01
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| Series: | Discover Oncology |
| Online Access: | https://doi.org/10.1007/s12672-025-02047-8 |
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| author | Dong Liu Jinju Xia Ruilin He Ronghua Zhu |
| author_facet | Dong Liu Jinju Xia Ruilin He Ronghua Zhu |
| author_sort | Dong Liu |
| collection | DOAJ |
| description | Abstract Objectives To investigate the causal relationship between the genetically predicted eosinophil counts and hepatocellular carcinoma (HCC) in East Asians. Additionally, we aimed to explore the infiltration and clinical impact of eosinophils in HCC using the Gene Expression Profiling Interactive Analysis (GEPIA). Methods We utilized a discovery set to explore the correlation between eosinophil counts and HCC, and validated the findings using a validation set. We employed multivariate mendelian randomization (MR) analysis to exclude confounding factors. The results from the discovery set and the validation set were combined through meta-analysis. The GEPIA online platform was utilized to analyze the infiltration and clinical impact of eosinophils in HCC. Results The genetically predicted counts of eosinophils were associated with a reduced risk of HCC, with meta-analysis yielding an OR of 0.662 (95% CI: 0.532–0.823). The eosinophil infiltration was significantly lower in HCC tissue compared to normal liver tissue (F = 4.90, P = 0.03), and the survival outcomes were not affected by the level of eosinophil infiltration. Conclusion Our findings indicate a potential causal link between lower eosinophil counts and the occurrence of HCC in the East Asian population, offering valuable insights into the prevention and understanding of HCC. |
| format | Article |
| id | doaj-art-f09aad2d3eb2413b8bd74dc92249e1fd |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-f09aad2d3eb2413b8bd74dc92249e1fd2025-08-20T03:01:39ZengSpringerDiscover Oncology2730-60112025-03-011611710.1007/s12672-025-02047-8The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization studyDong Liu0Jinju Xia1Ruilin He2Ronghua Zhu3Department of Imaging and Nuclear Medicine, Third Affiliated Hospital of Naval Medical UniversityDepartment of Imaging and Nuclear Medicine, Third Affiliated Hospital of Naval Medical UniversitySchool of Health Science and Engineering, University of Shanghai for Science and TechnologyDepartment of Imaging and Nuclear Medicine, Third Affiliated Hospital of Naval Medical UniversityAbstract Objectives To investigate the causal relationship between the genetically predicted eosinophil counts and hepatocellular carcinoma (HCC) in East Asians. Additionally, we aimed to explore the infiltration and clinical impact of eosinophils in HCC using the Gene Expression Profiling Interactive Analysis (GEPIA). Methods We utilized a discovery set to explore the correlation between eosinophil counts and HCC, and validated the findings using a validation set. We employed multivariate mendelian randomization (MR) analysis to exclude confounding factors. The results from the discovery set and the validation set were combined through meta-analysis. The GEPIA online platform was utilized to analyze the infiltration and clinical impact of eosinophils in HCC. Results The genetically predicted counts of eosinophils were associated with a reduced risk of HCC, with meta-analysis yielding an OR of 0.662 (95% CI: 0.532–0.823). The eosinophil infiltration was significantly lower in HCC tissue compared to normal liver tissue (F = 4.90, P = 0.03), and the survival outcomes were not affected by the level of eosinophil infiltration. Conclusion Our findings indicate a potential causal link between lower eosinophil counts and the occurrence of HCC in the East Asian population, offering valuable insights into the prevention and understanding of HCC.https://doi.org/10.1007/s12672-025-02047-8 |
| spellingShingle | Dong Liu Jinju Xia Ruilin He Ronghua Zhu The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study Discover Oncology |
| title | The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study |
| title_full | The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study |
| title_fullStr | The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study |
| title_full_unstemmed | The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study |
| title_short | The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study |
| title_sort | causal relationship between eosinophil counts and hepatocellular carcinoma in east asians evidence from a mendelian randomization study |
| url | https://doi.org/10.1007/s12672-025-02047-8 |
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