Hedgehog and Resident Vascular Stem Cell Fate
The Hedgehog pathway is a pivotal morphogenic driver during embryonic development and a key regulator of adult stem cell self-renewal. The discovery of resident multipotent vascular stem cells and adventitial progenitors within the vessel wall has transformed our understanding of the origin of media...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/468428 |
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| _version_ | 1850163357030547456 |
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| author | Ciaran J. Mooney Roya Hakimjavadi Emma Fitzpatrick Eimear Kennedy Dermot Walls David Morrow Eileen M. Redmond Paul A. Cahill |
| author_facet | Ciaran J. Mooney Roya Hakimjavadi Emma Fitzpatrick Eimear Kennedy Dermot Walls David Morrow Eileen M. Redmond Paul A. Cahill |
| author_sort | Ciaran J. Mooney |
| collection | DOAJ |
| description | The Hedgehog pathway is a pivotal morphogenic driver during embryonic development and a key regulator of adult stem cell self-renewal. The discovery of resident multipotent vascular stem cells and adventitial progenitors within the vessel wall has transformed our understanding of the origin of medial and neointimal vascular smooth muscle cells (SMCs) during vessel repair in response to injury, lesion formation, and overall disease progression. This review highlights the importance of components of the Hh and Notch signalling pathways within the medial and adventitial regions of adult vessels, their recapitulation following vascular injury and disease progression, and their putative role in the maintenance and differentiation of resident vascular stem cells to vascular lineages from discrete niches within the vessel wall. |
| format | Article |
| id | doaj-art-f087c0a6b403440bbbf2d554eda18dfa |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f087c0a6b403440bbbf2d554eda18dfa2025-08-20T02:22:19ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/468428468428Hedgehog and Resident Vascular Stem Cell FateCiaran J. Mooney0Roya Hakimjavadi1Emma Fitzpatrick2Eimear Kennedy3Dermot Walls4David Morrow5Eileen M. Redmond6Paul A. Cahill7Vascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, IrelandVascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, IrelandVascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, IrelandVascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, IrelandSchool of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, IrelandDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USADepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USAVascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, IrelandThe Hedgehog pathway is a pivotal morphogenic driver during embryonic development and a key regulator of adult stem cell self-renewal. The discovery of resident multipotent vascular stem cells and adventitial progenitors within the vessel wall has transformed our understanding of the origin of medial and neointimal vascular smooth muscle cells (SMCs) during vessel repair in response to injury, lesion formation, and overall disease progression. This review highlights the importance of components of the Hh and Notch signalling pathways within the medial and adventitial regions of adult vessels, their recapitulation following vascular injury and disease progression, and their putative role in the maintenance and differentiation of resident vascular stem cells to vascular lineages from discrete niches within the vessel wall.http://dx.doi.org/10.1155/2015/468428 |
| spellingShingle | Ciaran J. Mooney Roya Hakimjavadi Emma Fitzpatrick Eimear Kennedy Dermot Walls David Morrow Eileen M. Redmond Paul A. Cahill Hedgehog and Resident Vascular Stem Cell Fate Stem Cells International |
| title | Hedgehog and Resident Vascular Stem Cell Fate |
| title_full | Hedgehog and Resident Vascular Stem Cell Fate |
| title_fullStr | Hedgehog and Resident Vascular Stem Cell Fate |
| title_full_unstemmed | Hedgehog and Resident Vascular Stem Cell Fate |
| title_short | Hedgehog and Resident Vascular Stem Cell Fate |
| title_sort | hedgehog and resident vascular stem cell fate |
| url | http://dx.doi.org/10.1155/2015/468428 |
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