Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.

<h4>Background</h4>Essential hypertension (EH) with anxiety or depression belongs to the category of psycho-cardiology. Hypertension is closely related to anxiety and depression. The adverse reactions of Western medicine are apparent and the compliance is poor. Supplementary and replacem...

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Main Authors: Xueyan Han, Xinxin Liu, Fengxing Zhong, Yiguo Wang, Qiming Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0254699&type=printable
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author Xueyan Han
Xinxin Liu
Fengxing Zhong
Yiguo Wang
Qiming Zhang
author_facet Xueyan Han
Xinxin Liu
Fengxing Zhong
Yiguo Wang
Qiming Zhang
author_sort Xueyan Han
collection DOAJ
description <h4>Background</h4>Essential hypertension (EH) with anxiety or depression belongs to the category of psycho-cardiology. Hypertension is closely related to anxiety and depression. The adverse reactions of Western medicine are apparent and the compliance is poor. Supplementary and replacement therapies have accumulated rich experience in clinical practices, which can reduce side effects and improve clinical efficacy. This study intends to use the Bayesian network meta-analysis (NMA) analysis method for the first time to gather randomized controlled trials (RCTs) related to complementary and alternative therapies in the treatment of hypertension with anxiety or depression disorder and rank efficacy and safety, to provide a reference basis for the treatment of hypertension with anxiety or depression disorder.<h4>Methods</h4>All randomized controlled trials (RCTs) and registered and ongoing trials of Chinese and English databases, related to supplementation and replacement therapies of EH with anxiety or depression disorder, published from initial state to February 2021, will be collected in the form of computer retrieval. Two researchers will independently screen the literature, extracting data, assessing bias risk and assessing heterogeneity. We will use software WinBUGS 1.4.3 and Stata 16.0 for pairwise meta-analysis and NMA to comprehensively evaluate various interventions. The quality of evidence will be evaluated through the Grading of Recommendations Assessment, Development and Evaluation (GRADE).<h4>Results</h4>This NMA will comprehensively compare and rank the efficacy and safety of a series of complementary and alternative therapies in treating EH with anxiety or depression disorder.<h4>Conclusion</h4>Supplementary and replacement therapies have accumulated rich experience of clinical practices in improving EH with anxiety or depression disorder. We expect that this NMA will guide practice and research by providing reliable evidence of evidence-based medicine for the treatment of EH with anxiety or depression disorder.<h4>Protocol registration number</h4>INPLASY202120068.
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spelling doaj-art-f06fb5eee8b74aafa5ad1fb79a7ab14e2025-01-24T05:31:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01167e025469910.1371/journal.pone.0254699Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.Xueyan HanXinxin LiuFengxing ZhongYiguo WangQiming Zhang<h4>Background</h4>Essential hypertension (EH) with anxiety or depression belongs to the category of psycho-cardiology. Hypertension is closely related to anxiety and depression. The adverse reactions of Western medicine are apparent and the compliance is poor. Supplementary and replacement therapies have accumulated rich experience in clinical practices, which can reduce side effects and improve clinical efficacy. This study intends to use the Bayesian network meta-analysis (NMA) analysis method for the first time to gather randomized controlled trials (RCTs) related to complementary and alternative therapies in the treatment of hypertension with anxiety or depression disorder and rank efficacy and safety, to provide a reference basis for the treatment of hypertension with anxiety or depression disorder.<h4>Methods</h4>All randomized controlled trials (RCTs) and registered and ongoing trials of Chinese and English databases, related to supplementation and replacement therapies of EH with anxiety or depression disorder, published from initial state to February 2021, will be collected in the form of computer retrieval. Two researchers will independently screen the literature, extracting data, assessing bias risk and assessing heterogeneity. We will use software WinBUGS 1.4.3 and Stata 16.0 for pairwise meta-analysis and NMA to comprehensively evaluate various interventions. The quality of evidence will be evaluated through the Grading of Recommendations Assessment, Development and Evaluation (GRADE).<h4>Results</h4>This NMA will comprehensively compare and rank the efficacy and safety of a series of complementary and alternative therapies in treating EH with anxiety or depression disorder.<h4>Conclusion</h4>Supplementary and replacement therapies have accumulated rich experience of clinical practices in improving EH with anxiety or depression disorder. We expect that this NMA will guide practice and research by providing reliable evidence of evidence-based medicine for the treatment of EH with anxiety or depression disorder.<h4>Protocol registration number</h4>INPLASY202120068.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0254699&type=printable
spellingShingle Xueyan Han
Xinxin Liu
Fengxing Zhong
Yiguo Wang
Qiming Zhang
Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
PLoS ONE
title Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_full Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_fullStr Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_full_unstemmed Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_short Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_sort comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder
url https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0254699&type=printable
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