Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3B +/- male mice

Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3B +/- male mice

Abstract The neuropeptide arginine-vasopressin (AVP) has been repeatedly associated with the autism spectrum disorder (ASD) but the underlying mechanisms remain unclear. As Shank3B +/- male mice, a model of ASD, exhibit deficits in sociability and social aggression, we focused on the lateral septum...

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Main Authors: Maria Helena Bortolozzo-Gleich, Guillaume Bouisset, Lan Geng, Antonia Ruiz Pino, Yuki Nomura, Shuting Han, Yulong Li, Félix Leroy
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61994-6
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