Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes
Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120–360 min as a compensation of the antidiabetic drug peak effect. No gluco...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0017 |
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| author | Sabadková Dana Franc Aleš Muselík Jan Neumann David |
| author_facet | Sabadková Dana Franc Aleš Muselík Jan Neumann David |
| author_sort | Sabadková Dana |
| collection | DOAJ |
| description | Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120–360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an ethylcellulose dispersion, which forms an insoluble semipermeable membrane and ensures delayed release. The release of glucose was assessed using dissolution and high-performance liquid chromatography. Dissolution profiles indicated the possibility of achieving the requested lag time using a combination of adequate compositions and coating concentrations. Lag times of 60, 240 and 360 min were achieved. The sample containing carboxymethyl starch was found to be most suitable for the intent of this work. |
| format | Article |
| id | doaj-art-f06d615fd8ce4330b4a26f3a1de5eb87 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-f06d615fd8ce4330b4a26f3a1de5eb872025-02-02T15:49:15ZengSciendoActa Pharmaceutica1846-95582016-06-0166225726710.1515/acph-2016-0017acph-2016-0017Coated pellets with delayed-release glucose for prevention of hypoglycemic episodesSabadková Dana0Franc Aleš1Muselík Jan2Neumann David3 Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 00 Brno, Czech Republic Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 00 Brno, Czech Republic Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 00 Brno, Czech Republic University Hospital, Department of Pediatrics, 500 05 Hradec Králové, Czech RepublicPatients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120–360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an ethylcellulose dispersion, which forms an insoluble semipermeable membrane and ensures delayed release. The release of glucose was assessed using dissolution and high-performance liquid chromatography. Dissolution profiles indicated the possibility of achieving the requested lag time using a combination of adequate compositions and coating concentrations. Lag times of 60, 240 and 360 min were achieved. The sample containing carboxymethyl starch was found to be most suitable for the intent of this work.https://doi.org/10.1515/acph-2016-0017hypoglycemiadiabetes mellituspelletsdelayed releaseglucosepellet evaluation |
| spellingShingle | Sabadková Dana Franc Aleš Muselík Jan Neumann David Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes Acta Pharmaceutica hypoglycemia diabetes mellitus pellets delayed release glucose pellet evaluation |
| title | Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes |
| title_full | Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes |
| title_fullStr | Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes |
| title_full_unstemmed | Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes |
| title_short | Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes |
| title_sort | coated pellets with delayed release glucose for prevention of hypoglycemic episodes |
| topic | hypoglycemia diabetes mellitus pellets delayed release glucose pellet evaluation |
| url | https://doi.org/10.1515/acph-2016-0017 |
| work_keys_str_mv | AT sabadkovadana coatedpelletswithdelayedreleaseglucoseforpreventionofhypoglycemicepisodes AT francales coatedpelletswithdelayedreleaseglucoseforpreventionofhypoglycemicepisodes AT muselikjan coatedpelletswithdelayedreleaseglucoseforpreventionofhypoglycemicepisodes AT neumanndavid coatedpelletswithdelayedreleaseglucoseforpreventionofhypoglycemicepisodes |