Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol [version 2; peer review: 3 approved]
Introduction Malaria in pregnancy remains a public health problem. The World Health Organization (WHO) recommends intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) to all pregnant women in moderate to high malaria transmission areas. Kenya's Ministry of Health recommend...
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F1000 Research Ltd
2025-04-01
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| Online Access: | https://open-research-europe.ec.europa.eu/articles/5-60/v2 |
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| author | Isabella Oyier Martin Rono Mainga Hamaluba Patience Kerubo Kiyuka Nelson Ouma Mark Muricho Amek Nyaguara Charles Muiruri |
| author_facet | Isabella Oyier Martin Rono Mainga Hamaluba Patience Kerubo Kiyuka Nelson Ouma Mark Muricho Amek Nyaguara Charles Muiruri |
| author_sort | Isabella Oyier |
| collection | DOAJ |
| description | Introduction Malaria in pregnancy remains a public health problem. The World Health Organization (WHO) recommends intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) to all pregnant women in moderate to high malaria transmission areas. Kenya's Ministry of Health recommends at least three doses of IPTp-SP (IPTp-SP3 +) to pregnant women in regions where malaria is endemic. Although SP remains cost-effective and effective for IPTp, there are two main challenges with the use of SP: i) widespread use of SP can lead to an increase in the prevalence of drug resistance molecular markers, including those encoding for Plasmodium falciparum dihydrofolate reductase (dhfr) and Pf dihydropteroate synthase (dhps) and ii) SP, used either for curative or preventive treatment, is associated with microscopic and sub microscopic gametocytaemia, both of which contribute to sustained malaria transmission. Our study aims to investigate the dynamics of Plasmodium falciparum gametocyte carriage in pregnant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi. Methods This will be a cross-sectional study and will recruit (N=462) expectant women attending antenatal care (ANC) clinics in four health facilities within the Kilifi Health and Demographic Surveillance Sites: Njunju, Pingilikani, Ngerenya, and Kilifi County Teaching and Referral Hospital (KCTRH). To be recruited into our study, women will need to be in their first or second pregnancy when they are more likely to have malaria and should have had at least one dose of sulfadoxine-pyrimethamine. Expected application of results Our study will provide information on the current status of malaria during pregnancy in Kilifi and the prevalence of gametocytes among expectant mothers on IPT-SP. The results of this study may help inform new interventions to prevent malaria during pregnancy, including adding a third drug to SP with probable gametocytocidal effects. |
| format | Article |
| id | doaj-art-f055b3e87fc14bb2bc05f05f01111925 |
| institution | DOAJ |
| issn | 2732-5121 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | F1000 Research Ltd |
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| series | Open Research Europe |
| spelling | doaj-art-f055b3e87fc14bb2bc05f05f011119252025-08-20T03:08:24ZengF1000 Research LtdOpen Research Europe2732-51212025-04-01510.12688/openreseurope.19356.221806Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol [version 2; peer review: 3 approved]Isabella Oyier0Martin Rono1Mainga Hamaluba2Patience Kerubo Kiyuka3https://orcid.org/0000-0002-3257-5920Nelson Ouma4Mark Muricho5Amek Nyaguara6Charles Muiruri7KEMRI Wellcome Trust Research Programme, Kilifi, 80108, KenyaCenter for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kilifi County, 80108, KenyaKEMRI Wellcome Trust Research Programme, Kilifi, 80108, KenyaCenter for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kilifi County, 80108, KenyaKEMRI Wellcome Trust Research Programme, Kilifi, 80108, KenyaKEMRI Wellcome Trust Research Programme, Kilifi, 80108, KenyaKEMRI Wellcome Trust Research Programme, Kilifi, 80108, KenyaKEMRI Wellcome Trust Research Programme, Kilifi, 80108, KenyaIntroduction Malaria in pregnancy remains a public health problem. The World Health Organization (WHO) recommends intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) to all pregnant women in moderate to high malaria transmission areas. Kenya's Ministry of Health recommends at least three doses of IPTp-SP (IPTp-SP3 +) to pregnant women in regions where malaria is endemic. Although SP remains cost-effective and effective for IPTp, there are two main challenges with the use of SP: i) widespread use of SP can lead to an increase in the prevalence of drug resistance molecular markers, including those encoding for Plasmodium falciparum dihydrofolate reductase (dhfr) and Pf dihydropteroate synthase (dhps) and ii) SP, used either for curative or preventive treatment, is associated with microscopic and sub microscopic gametocytaemia, both of which contribute to sustained malaria transmission. Our study aims to investigate the dynamics of Plasmodium falciparum gametocyte carriage in pregnant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi. Methods This will be a cross-sectional study and will recruit (N=462) expectant women attending antenatal care (ANC) clinics in four health facilities within the Kilifi Health and Demographic Surveillance Sites: Njunju, Pingilikani, Ngerenya, and Kilifi County Teaching and Referral Hospital (KCTRH). To be recruited into our study, women will need to be in their first or second pregnancy when they are more likely to have malaria and should have had at least one dose of sulfadoxine-pyrimethamine. Expected application of results Our study will provide information on the current status of malaria during pregnancy in Kilifi and the prevalence of gametocytes among expectant mothers on IPT-SP. The results of this study may help inform new interventions to prevent malaria during pregnancy, including adding a third drug to SP with probable gametocytocidal effects.https://open-research-europe.ec.europa.eu/articles/5-60/v2malaria Plasmodium falciparum sulfadoxine-pyrimethamine intermittent preventive treatment expectant mothers pregnant womeneng |
| spellingShingle | Isabella Oyier Martin Rono Mainga Hamaluba Patience Kerubo Kiyuka Nelson Ouma Mark Muricho Amek Nyaguara Charles Muiruri Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol [version 2; peer review: 3 approved] Open Research Europe malaria Plasmodium falciparum sulfadoxine-pyrimethamine intermittent preventive treatment expectant mothers pregnant women eng |
| title | Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol [version 2; peer review: 3 approved] |
| title_full | Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol [version 2; peer review: 3 approved] |
| title_fullStr | Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol [version 2; peer review: 3 approved] |
| title_full_unstemmed | Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol [version 2; peer review: 3 approved] |
| title_short | Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol [version 2; peer review: 3 approved] |
| title_sort | investigating the dynamics of plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine pyrimethamine in kilifi study protocol version 2 peer review 3 approved |
| topic | malaria Plasmodium falciparum sulfadoxine-pyrimethamine intermittent preventive treatment expectant mothers pregnant women eng |
| url | https://open-research-europe.ec.europa.eu/articles/5-60/v2 |
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