Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study.

<h4>Background</h4>Overactive bladder (OAB) is a common disorder, particularly in women, and its symptoms, including urgency, frequency, and nocturia, can significantly affect quality of life. The cardiometabolic index (CMI) is a novel metabolic risk indicator that has been receiving mor...

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Main Authors: Junhua Li, Min He, Yu Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0314594
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author Junhua Li
Min He
Yu Zhou
author_facet Junhua Li
Min He
Yu Zhou
author_sort Junhua Li
collection DOAJ
description <h4>Background</h4>Overactive bladder (OAB) is a common disorder, particularly in women, and its symptoms, including urgency, frequency, and nocturia, can significantly affect quality of life. The cardiometabolic index (CMI) is a novel metabolic risk indicator that has been receiving more attention lately. This study investigated the association between CMI and OAB in adult women.<h4>Methods</h4>A cross-sectional analysis was performed using data from the National Health and Nutrition Examination Survey (NHANES) covering the years 2007 to 2018, including 6323 female participants. CMI was calculated based on waist-to-height ratio, triglyceride, and HDL cholesterol levels, while OAB was assessed using the overactive bladder symptom score (OABSS). The association between CMI and OAB was evaluated through multivariate logistic regression, generalized additive models (GAM), smoothing curve fitting, and subgroup analysis. We finally included male participants for sensitivity analysis.<h4>Results</h4>A significant positive association was found between female CMI and OAB prevalence (OR = 1.46, 95% CI: 1.29-1.65). When compared to the lowest CMI quartile (Q1), women in the highest CMI quartile were 70% more likely to have OAB (OR = 1.70, 95% CI: 1.42-2.04). Smoothed curve fitting analysis showed a linear association between CMI and OAB. Subgroup analysis revealed that the association between CMI and OAB was stronger in women aged 20-50 years as well as in women without hypertension. Sensitivity analysis confirmed the robustness of our result.<h4>Conclusion</h4>CMI was significantly and positively associated with the prevalence of OAB, especially in women aged 20-50 years without hypertension. This finding provides a new perspective on metabolic risk management and may contribute to the early prevention and improvement of bladder function in women.
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spelling doaj-art-f041423b21c94ed494aa916cf56382662025-02-05T05:31:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031459410.1371/journal.pone.0314594Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study.Junhua LiMin HeYu Zhou<h4>Background</h4>Overactive bladder (OAB) is a common disorder, particularly in women, and its symptoms, including urgency, frequency, and nocturia, can significantly affect quality of life. The cardiometabolic index (CMI) is a novel metabolic risk indicator that has been receiving more attention lately. This study investigated the association between CMI and OAB in adult women.<h4>Methods</h4>A cross-sectional analysis was performed using data from the National Health and Nutrition Examination Survey (NHANES) covering the years 2007 to 2018, including 6323 female participants. CMI was calculated based on waist-to-height ratio, triglyceride, and HDL cholesterol levels, while OAB was assessed using the overactive bladder symptom score (OABSS). The association between CMI and OAB was evaluated through multivariate logistic regression, generalized additive models (GAM), smoothing curve fitting, and subgroup analysis. We finally included male participants for sensitivity analysis.<h4>Results</h4>A significant positive association was found between female CMI and OAB prevalence (OR = 1.46, 95% CI: 1.29-1.65). When compared to the lowest CMI quartile (Q1), women in the highest CMI quartile were 70% more likely to have OAB (OR = 1.70, 95% CI: 1.42-2.04). Smoothed curve fitting analysis showed a linear association between CMI and OAB. Subgroup analysis revealed that the association between CMI and OAB was stronger in women aged 20-50 years as well as in women without hypertension. Sensitivity analysis confirmed the robustness of our result.<h4>Conclusion</h4>CMI was significantly and positively associated with the prevalence of OAB, especially in women aged 20-50 years without hypertension. This finding provides a new perspective on metabolic risk management and may contribute to the early prevention and improvement of bladder function in women.https://doi.org/10.1371/journal.pone.0314594
spellingShingle Junhua Li
Min He
Yu Zhou
Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study.
PLoS ONE
title Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study.
title_full Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study.
title_fullStr Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study.
title_full_unstemmed Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study.
title_short Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study.
title_sort association between cardiometabolic index and overactive bladder in adult american women a cross sectional study
url https://doi.org/10.1371/journal.pone.0314594
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AT minhe associationbetweencardiometabolicindexandoveractivebladderinadultamericanwomenacrosssectionalstudy
AT yuzhou associationbetweencardiometabolicindexandoveractivebladderinadultamericanwomenacrosssectionalstudy