Synthesis of Bispidine-Based Prostate-Specific Membrane Antigen-Targeted Conjugate and Initial Investigations

Synthesis of Bispidine-Based Prostate-Specific Membrane Antigen-Targeted Conjugate and Initial Investigations

Nowadays, PSMA ligands are widely used for radiotheragnostic purposes in prostate cancer. The synthesis of a PSMA-Bisp conjugate was developed and realized with good yield (overall yield ~58% for the last two steps). All newly synthesized compounds were characterized by physicochemical methods: <...

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Bibliographic Details
Main Authors: Aleksei E. Machulkin, Stanislav A. Petrov, Maria D. Kraynova, Anastasiia S. Garanina, Bayirta V. Egorova, Roman V. Timoshenko, Alexander N. Vaneev, Alexander S. Erofeev, Anna B. Priselkova, Mikhail A. Kalinin, Aleksei V. Medved′ko, Stepan N. Kalmykov, Elena K. Beloglazkina, Sergey Z. Vatsadze
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Organics
Subjects:
PSMA
bispidine bifunctional chelator
copper-64
complexation
delivery
Online Access:https://www.mdpi.com/2673-401X/6/1/7
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