Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats)
Abstract The main objective of the present study was to investigate the toxicity of orally administered organophosphorus dimethoate pesticide in Rattus norvegicus on the basis of biochemical alterations in the blood. There was a total of eight groups: two control groups and six treatment groups. Alb...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88023-2 |
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| author | Nida Saleem Mushtaq Hussain Lashari Hafiz Ishfaq Ahmad |
| author_facet | Nida Saleem Mushtaq Hussain Lashari Hafiz Ishfaq Ahmad |
| author_sort | Nida Saleem |
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| description | Abstract The main objective of the present study was to investigate the toxicity of orally administered organophosphorus dimethoate pesticide in Rattus norvegicus on the basis of biochemical alterations in the blood. There was a total of eight groups: two control groups and six treatment groups. Albino rats of the exposed groups were fed simple laboratory chow along with a low dose: five milliliters were given to the T1 group; the medium dose, ten milliliters, was given to the T2 group; and the high dose, twenty milliliters, was given to the T3 group of dimethoate pesticide for thirty, sixty, or ninety days under controlled laboratory conditions. At the end of the experiment, any weight gain, changes in the blood parameters, or biochemical changes were determined. The results revealed increases in the total glucose, aspartate aminotransferase, and alanine aminotransferase levels in the exposed groups of both genders of albino rats. There were decreases in the levels of urea, uric acid and total bilirubin in the exposed groups of both genders of albino rats. These effects did not vary between the sexes. This study provides a foundation for further research on the long-term effects of dimethoate and similar pesticides, promoting the development of safer alternatives. |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-f03b0c4ef6024e0c9cc947267c4f28fa2025-02-09T12:37:14ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-025-88023-2Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats)Nida Saleem0Mushtaq Hussain Lashari1Hafiz Ishfaq Ahmad2Department of Zoology, The Islamia UniversityDepartment of Zoology, The Islamia UniversityDepartment of Animal Breeding and Genetics, Faculty of Veterinary and Animal Sciences, The Islamia UniversityAbstract The main objective of the present study was to investigate the toxicity of orally administered organophosphorus dimethoate pesticide in Rattus norvegicus on the basis of biochemical alterations in the blood. There was a total of eight groups: two control groups and six treatment groups. Albino rats of the exposed groups were fed simple laboratory chow along with a low dose: five milliliters were given to the T1 group; the medium dose, ten milliliters, was given to the T2 group; and the high dose, twenty milliliters, was given to the T3 group of dimethoate pesticide for thirty, sixty, or ninety days under controlled laboratory conditions. At the end of the experiment, any weight gain, changes in the blood parameters, or biochemical changes were determined. The results revealed increases in the total glucose, aspartate aminotransferase, and alanine aminotransferase levels in the exposed groups of both genders of albino rats. There were decreases in the levels of urea, uric acid and total bilirubin in the exposed groups of both genders of albino rats. These effects did not vary between the sexes. This study provides a foundation for further research on the long-term effects of dimethoate and similar pesticides, promoting the development of safer alternatives.https://doi.org/10.1038/s41598-025-88023-2PesticideBiochemical changesLaboratory feedExposed groups |
| spellingShingle | Nida Saleem Mushtaq Hussain Lashari Hafiz Ishfaq Ahmad Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats) Scientific Reports Pesticide Biochemical changes Laboratory feed Exposed groups |
| title | Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats) |
| title_full | Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats) |
| title_fullStr | Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats) |
| title_full_unstemmed | Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats) |
| title_short | Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats) |
| title_sort | orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental rattus norvegicus albino rats |
| topic | Pesticide Biochemical changes Laboratory feed Exposed groups |
| url | https://doi.org/10.1038/s41598-025-88023-2 |
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