Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis
Background. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods. A sys...
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| Format: | Article |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/5715403 |
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| author | Jun-Zhen Li Jie-Yao Li Ting-Feng Wu Ji-Hao Xu Can-Ze Huang Di Cheng Qi-Kui Chen Tao Yu |
| author_facet | Jun-Zhen Li Jie-Yao Li Ting-Feng Wu Ji-Hao Xu Can-Ze Huang Di Cheng Qi-Kui Chen Tao Yu |
| author_sort | Jun-Zhen Li |
| collection | DOAJ |
| description | Background. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods. A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. Results. 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P<0.001). The difference was significant in comparison between type 2 DM group and non-DM group (OR = 2.05), but not in that between type 1 DM group and non-DM group (OR = 1.23, 95% CI: 0.77–1.96, P=0.38). Conclusion. Our meta-analysis suggested that there is significantly higher prevalence of H. pylori infection in DM patients as compared to non-DM individuals. And the difference is associated with type 2 DM but not type 1 DM. |
| format | Article |
| id | doaj-art-f039dfa1de1f4f3aa02d71e64cbc8f56 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f039dfa1de1f4f3aa02d71e64cbc8f562025-02-03T05:51:21ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/57154035715403Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-AnalysisJun-Zhen Li0Jie-Yao Li1Ting-Feng Wu2Ji-Hao Xu3Can-Ze Huang4Di Cheng5Qi-Kui Chen6Tao Yu7Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120 Guangzhou, Guangdong, ChinaDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120 Guangzhou, Guangdong, ChinaDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120 Guangzhou, Guangdong, ChinaDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120 Guangzhou, Guangdong, ChinaDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120 Guangzhou, Guangdong, ChinaDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120 Guangzhou, Guangdong, ChinaDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120 Guangzhou, Guangdong, ChinaDepartment of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120 Guangzhou, Guangdong, ChinaBackground. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods. A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. Results. 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P<0.001). The difference was significant in comparison between type 2 DM group and non-DM group (OR = 2.05), but not in that between type 1 DM group and non-DM group (OR = 1.23, 95% CI: 0.77–1.96, P=0.38). Conclusion. Our meta-analysis suggested that there is significantly higher prevalence of H. pylori infection in DM patients as compared to non-DM individuals. And the difference is associated with type 2 DM but not type 1 DM.http://dx.doi.org/10.1155/2017/5715403 |
| spellingShingle | Jun-Zhen Li Jie-Yao Li Ting-Feng Wu Ji-Hao Xu Can-Ze Huang Di Cheng Qi-Kui Chen Tao Yu Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis Gastroenterology Research and Practice |
| title | Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis |
| title_full | Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis |
| title_fullStr | Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis |
| title_full_unstemmed | Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis |
| title_short | Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis |
| title_sort | helicobacter pylori infection is associated with type 2 diabetes not type 1 diabetes an updated meta analysis |
| url | http://dx.doi.org/10.1155/2017/5715403 |
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