Interaction of norsecurinine-type monomeric and dimeric alkaloids with α-tubulin: a molecular docking study

Aim: New microtubule-targeting agents are needed to improve cancer treatment. The recent characterization of the anticancer alkaloid securinine as a tubulin-binding agent prompted us to explore the interaction of related monomeric and dimeric analogues with tubulin. The interaction between the α/β-t...

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Main Authors: Gérard Vergoten, Christian Bailly
Format: Article
Language:English
Published: Open Exploration 2024-05-01
Series:Exploration of Drug Science
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Online Access:https://www.explorationpub.com/uploads/Article/A100847/100847.pdf
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