Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study
Purpose: To characterize causes of death in patients with bone metastases and to support data-driven approaches to survivorship planning and clinical decision-making in this population. Methods: Using data from the SEER registry (2010–2021), we identified 186,404 patients with newly diagnosed bone m...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Journal of Bone Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137425000491 |
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| author | Xia Yan Hongyu Liu Xueqi Bai Jin Xu Xiaojun Lou Lai Wang |
| author_facet | Xia Yan Hongyu Liu Xueqi Bai Jin Xu Xiaojun Lou Lai Wang |
| author_sort | Xia Yan |
| collection | DOAJ |
| description | Purpose: To characterize causes of death in patients with bone metastases and to support data-driven approaches to survivorship planning and clinical decision-making in this population. Methods: Using data from the SEER registry (2010–2021), we identified 186,404 patients with newly diagnosed bone metastases. Causes of death were classified as related to the cancer-specific, non-cancer, or subsequent cancer. Standardized mortality ratios (SMRs) were calculated to assess excess non-cancer mortality relative to the general population. Results: During follow-up, 133,393 patients (71.5 %) died from the primary cancer, 11,062 (5.9 %) from non-cancer causes, and 929 (0.5 %) from other malignancies. Although cancer remained the predominant cause of death, non-cancer mortality increased over time (from 6.3 % in 2010 to 9.5 % in 2021). Cardiovascular disease, COPD, and cerebrovascular events were the most common non-cancer causes. The greatest excess mortality was observed for HIV-related infection conditions (SMR: 13.24), septicemia (10.60), suicide (6.68), and pneumonia/influenza (6.04). Conclusion: Non-cancer mortality is an increasingly important contributor to death among patients with bone metastases, underscoring the need for targeted prevention strategies for infections, cardiovascular disease, and other avoidable causes in this vulnerable population. |
| format | Article |
| id | doaj-art-f0242913677a46bba3aed5587e703cef |
| institution | Kabale University |
| issn | 2212-1374 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj-art-f0242913677a46bba3aed5587e703cef2025-08-23T04:48:20ZengElsevierJournal of Bone Oncology2212-13742025-10-015410070810.1016/j.jbo.2025.100708Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based studyXia Yan0Hongyu Liu1Xueqi Bai2Jin Xu3Xiaojun Lou4Lai Wang5Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, ChinaCancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, ChinaJiaxing Hospital of Traditional Chinese Medicine, Jiaxing University Affiliated TCM Hospital, Jiaxing, Zhejiang 314000, ChinaJiaxing Hospital of Traditional Chinese Medicine, Jiaxing University Affiliated TCM Hospital, Jiaxing, Zhejiang 314000, ChinaJiaxing Hospital of Traditional Chinese Medicine, Jiaxing University Affiliated TCM Hospital, Jiaxing, Zhejiang 314000, China; Corresponding author.Purpose: To characterize causes of death in patients with bone metastases and to support data-driven approaches to survivorship planning and clinical decision-making in this population. Methods: Using data from the SEER registry (2010–2021), we identified 186,404 patients with newly diagnosed bone metastases. Causes of death were classified as related to the cancer-specific, non-cancer, or subsequent cancer. Standardized mortality ratios (SMRs) were calculated to assess excess non-cancer mortality relative to the general population. Results: During follow-up, 133,393 patients (71.5 %) died from the primary cancer, 11,062 (5.9 %) from non-cancer causes, and 929 (0.5 %) from other malignancies. Although cancer remained the predominant cause of death, non-cancer mortality increased over time (from 6.3 % in 2010 to 9.5 % in 2021). Cardiovascular disease, COPD, and cerebrovascular events were the most common non-cancer causes. The greatest excess mortality was observed for HIV-related infection conditions (SMR: 13.24), septicemia (10.60), suicide (6.68), and pneumonia/influenza (6.04). Conclusion: Non-cancer mortality is an increasingly important contributor to death among patients with bone metastases, underscoring the need for targeted prevention strategies for infections, cardiovascular disease, and other avoidable causes in this vulnerable population.http://www.sciencedirect.com/science/article/pii/S2212137425000491Bone metastasesCause of deathCancer patientsSurvivorship |
| spellingShingle | Xia Yan Hongyu Liu Xueqi Bai Jin Xu Xiaojun Lou Lai Wang Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study Journal of Bone Oncology Bone metastases Cause of death Cancer patients Survivorship |
| title | Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study |
| title_full | Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study |
| title_fullStr | Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study |
| title_full_unstemmed | Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study |
| title_short | Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study |
| title_sort | comprehensive analysis of cancer and non cancer mortality in patients with bone metastases a population based study |
| topic | Bone metastases Cause of death Cancer patients Survivorship |
| url | http://www.sciencedirect.com/science/article/pii/S2212137425000491 |
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