Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targets
Abstract Super-enhancers (SEs) represent a distinct category of cis-regulatory elements notable for their robust transcriptional activation capabilities. In tumor cells, SEs intricately regulate the expression of oncogenes and pivotal cancer-associated signaling pathways, offering significant potent...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-024-03599-5 |
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| author | Xuejin Lu Meizi Zhu Xingyue Pei Jinhu Ma Rui Wang Yi Wang Shuwen Chen Yan Yan Yaling Zhu |
| author_facet | Xuejin Lu Meizi Zhu Xingyue Pei Jinhu Ma Rui Wang Yi Wang Shuwen Chen Yan Yan Yaling Zhu |
| author_sort | Xuejin Lu |
| collection | DOAJ |
| description | Abstract Super-enhancers (SEs) represent a distinct category of cis-regulatory elements notable for their robust transcriptional activation capabilities. In tumor cells, SEs intricately regulate the expression of oncogenes and pivotal cancer-associated signaling pathways, offering significant potential for cancer treatment. However, few studies have systematically discussed the crucial role of SEs in hepatocellular carcinoma (HCC), which is one of the most common liver cancers with late-stage diagnosis and limited treatment methods for advanced disease. Herein, we first summarize the identification methods and the intricate processes of formation and organization of super-enhancers. Subsequently, we delve into the roles and molecular mechanisms of SEs within the framework of HCC. Finally, we discuss the inhibitors targeting the key SE-components and their potential effects on the treatment of HCC. In conclusion, this review meticulously encapsulates the distinctive characteristics of SEs and underscores their pivotal roles in the context of hepatocellular carcinoma, presenting a novel perspective on the potential of super-enhancers as emerging therapeutic targets for HCC. |
| format | Article |
| id | doaj-art-f0144a9a15fb447bab302258f7ffe909 |
| institution | Kabale University |
| issn | 1475-2867 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-f0144a9a15fb447bab302258f7ffe9092025-01-12T12:40:41ZengBMCCancer Cell International1475-28672025-01-0125111110.1186/s12935-024-03599-5Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targetsXuejin Lu0Meizi Zhu1Xingyue Pei2Jinhu Ma3Rui Wang4Yi Wang5Shuwen Chen6Yan Yan7Yaling Zhu8Department of Pathophysiology, College of Basic Medical Science, Anhui Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, Anhui Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, Anhui Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, Anhui Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, Anhui Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, Anhui Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, Anhui Medical UniversityLaboratory Animal Research Center, College of Basic Medical Science, Anhui Medical UniversityDepartment of Pathophysiology, College of Basic Medical Science, Anhui Medical UniversityAbstract Super-enhancers (SEs) represent a distinct category of cis-regulatory elements notable for their robust transcriptional activation capabilities. In tumor cells, SEs intricately regulate the expression of oncogenes and pivotal cancer-associated signaling pathways, offering significant potential for cancer treatment. However, few studies have systematically discussed the crucial role of SEs in hepatocellular carcinoma (HCC), which is one of the most common liver cancers with late-stage diagnosis and limited treatment methods for advanced disease. Herein, we first summarize the identification methods and the intricate processes of formation and organization of super-enhancers. Subsequently, we delve into the roles and molecular mechanisms of SEs within the framework of HCC. Finally, we discuss the inhibitors targeting the key SE-components and their potential effects on the treatment of HCC. In conclusion, this review meticulously encapsulates the distinctive characteristics of SEs and underscores their pivotal roles in the context of hepatocellular carcinoma, presenting a novel perspective on the potential of super-enhancers as emerging therapeutic targets for HCC.https://doi.org/10.1186/s12935-024-03599-5Hepatocellular carcinomaSuper-enhancerTherapeutic targets |
| spellingShingle | Xuejin Lu Meizi Zhu Xingyue Pei Jinhu Ma Rui Wang Yi Wang Shuwen Chen Yan Yan Yaling Zhu Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targets Cancer Cell International Hepatocellular carcinoma Super-enhancer Therapeutic targets |
| title | Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targets |
| title_full | Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targets |
| title_fullStr | Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targets |
| title_full_unstemmed | Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targets |
| title_short | Super-enhancers in hepatocellular carcinoma: regulatory mechanism and therapeutic targets |
| title_sort | super enhancers in hepatocellular carcinoma regulatory mechanism and therapeutic targets |
| topic | Hepatocellular carcinoma Super-enhancer Therapeutic targets |
| url | https://doi.org/10.1186/s12935-024-03599-5 |
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