Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis
Abstract Stroke poses a significant mortality threat and frequently results in survivors experiencing varying degrees of residual disability. The objective of this meta-analysis was to elucidate the association between C-reactive protein-to-albumin ratio (CAR) and prognosis in patients with stroke....
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| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-07327-5 |
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| author | Jingxian Yang Yongjie Chen Jun Wan Feina Li Xinyu Yang Binger Shen Na Li Jiajia Didi Lijiao Zhou Yu Zhang |
| author_facet | Jingxian Yang Yongjie Chen Jun Wan Feina Li Xinyu Yang Binger Shen Na Li Jiajia Didi Lijiao Zhou Yu Zhang |
| author_sort | Jingxian Yang |
| collection | DOAJ |
| description | Abstract Stroke poses a significant mortality threat and frequently results in survivors experiencing varying degrees of residual disability. The objective of this meta-analysis was to elucidate the association between C-reactive protein-to-albumin ratio (CAR) and prognosis in patients with stroke. We searched the databases of PubMed, Embase, the Cochrane Library, and CNKI for relevant studies up to 26th January 2024. The quality of the included studies was evaluated using the Newcastle Ottawa Quality Assessment Scale (NOS). Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association between CAR and poor functional outcomes and mortality. A total of nine studies with 2954 patients were included. The pooled results demonstrated that elevated CAR was associated with poor functional outcomes in patients with stroke (OR: 2.24; 95% CI: 1.81–2.78; P < 0.00001). Similarly, elevated CAR was associated with mortality in patients with stroke (OR: 2.11; 95% CI: 1.51–2.94; P < 0.0001). CAR has prognostic value for poor functional outcomes and mortality in patients with stroke. |
| format | Article |
| id | doaj-art-effbdc83969543089d7be22dc73142ea |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-effbdc83969543089d7be22dc73142ea2025-08-20T03:38:12ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-07327-5Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysisJingxian Yang0Yongjie Chen1Jun Wan2Feina Li3Xinyu Yang4Binger Shen5Na Li6Jiajia Didi7Lijiao Zhou8Yu Zhang9Center for Evidence-based Medicine, Affiliated Hospital of Chengdu UniversityDepartment of critical care medicine, Affiliated Hospital of Chengdu UniversityCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu UniversityDepartment of critical care medicine, Affiliated Hospital of Chengdu UniversityCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu UniversityDepartment of critical care medicine, Affiliated Hospital of Chengdu UniversityCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu UniversityDepartment of Neurosurgery, Affiliated Hospital of Chengdu UniversityDepartment of critical care medicine, Affiliated Hospital of Chengdu UniversityCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu UniversityAbstract Stroke poses a significant mortality threat and frequently results in survivors experiencing varying degrees of residual disability. The objective of this meta-analysis was to elucidate the association between C-reactive protein-to-albumin ratio (CAR) and prognosis in patients with stroke. We searched the databases of PubMed, Embase, the Cochrane Library, and CNKI for relevant studies up to 26th January 2024. The quality of the included studies was evaluated using the Newcastle Ottawa Quality Assessment Scale (NOS). Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association between CAR and poor functional outcomes and mortality. A total of nine studies with 2954 patients were included. The pooled results demonstrated that elevated CAR was associated with poor functional outcomes in patients with stroke (OR: 2.24; 95% CI: 1.81–2.78; P < 0.00001). Similarly, elevated CAR was associated with mortality in patients with stroke (OR: 2.11; 95% CI: 1.51–2.94; P < 0.0001). CAR has prognostic value for poor functional outcomes and mortality in patients with stroke.https://doi.org/10.1038/s41598-025-07327-5C-reactive proteinAlbuminStrokeMortalityMeta-analysis |
| spellingShingle | Jingxian Yang Yongjie Chen Jun Wan Feina Li Xinyu Yang Binger Shen Na Li Jiajia Didi Lijiao Zhou Yu Zhang Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis Scientific Reports C-reactive protein Albumin Stroke Mortality Meta-analysis |
| title | Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis |
| title_full | Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis |
| title_fullStr | Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis |
| title_full_unstemmed | Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis |
| title_short | Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis |
| title_sort | prognostic value of the c reactive protein to albumin ratio in patients with stroke a meta analysis |
| topic | C-reactive protein Albumin Stroke Mortality Meta-analysis |
| url | https://doi.org/10.1038/s41598-025-07327-5 |
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