Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form
Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/6284764 |
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| author | Ibtissem Ben Nacef Sabrine Mekni Chedi Mhedhebi Ines Riahi Imen Rojbi Mchirgui Nadia Karima Khiari |
| author_facet | Ibtissem Ben Nacef Sabrine Mekni Chedi Mhedhebi Ines Riahi Imen Rojbi Mchirgui Nadia Karima Khiari |
| author_sort | Ibtissem Ben Nacef |
| collection | DOAJ |
| description | Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare. |
| format | Article |
| id | doaj-art-eff667d3eb2f4bd6bbe1c99d7eae975b |
| institution | DOAJ |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-eff667d3eb2f4bd6bbe1c99d7eae975b2025-08-20T03:21:19ZengWileyCase Reports in Endocrinology2090-65012090-651X2020-01-01202010.1155/2020/62847646284764Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated FormIbtissem Ben Nacef0Sabrine Mekni1Chedi Mhedhebi2Ines Riahi3Imen Rojbi4Mchirgui Nadia5Karima Khiari6Department of Endocrinology, Charles Nicolle Hospital, Tunis, TunisiaDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, TunisiaDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, TunisiaDepartment of Otorhinolaryngology-Head and Neck Surgery, Charles Nicolle Hospital, Tunis, TunisiaDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, TunisiaDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, TunisiaDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, TunisiaLangerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare.http://dx.doi.org/10.1155/2020/6284764 |
| spellingShingle | Ibtissem Ben Nacef Sabrine Mekni Chedi Mhedhebi Ines Riahi Imen Rojbi Mchirgui Nadia Karima Khiari Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form Case Reports in Endocrinology |
| title | Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form |
| title_full | Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form |
| title_fullStr | Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form |
| title_full_unstemmed | Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form |
| title_short | Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form |
| title_sort | langerhans cell histiocytosis of the thyroid leading to the diagnosis of a disseminated form |
| url | http://dx.doi.org/10.1155/2020/6284764 |
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