Post-infectious cough in patients with obesity: an observational study
BackgroundUpper respiratory tract infection (URTI) can lead to post-infectious cough (PIC). It is currently unclear the current status and influencing factors of PIC in patients with obesity.MethodsData were collected from patients who visited the institution’s bariatric surgery clinic, between June...
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Frontiers Media S.A.
2025-07-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1460929/full |
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| author | Yin Xian Yuan Zhang Xiangxin Kong Ke Song |
| author_facet | Yin Xian Yuan Zhang Xiangxin Kong Ke Song |
| author_sort | Yin Xian |
| collection | DOAJ |
| description | BackgroundUpper respiratory tract infection (URTI) can lead to post-infectious cough (PIC). It is currently unclear the current status and influencing factors of PIC in patients with obesity.MethodsData were collected from patients who visited the institution’s bariatric surgery clinic, between June and November 2022, but did not undergo surgery. Follow-up calls will be conducted in early January 2023, and whether these patients develop URTI and cough in December 2022 will be recorded. For patients with URTI and cough, the occurrence of accompanying symptoms during the course of the disease will be recorded. Then, in late February 2023, we will assess whether the cough or other accompanying symptoms have completely resolved within 8 weeks. Logistic regression analyzed the influencing factors of URTI developing into PIC in obese patients. Subgroup analyzes were used to assess interaction effects.ResultsOut of 286 study participants, 54 (18.9%) had a PIC. Waist circumference (WC) [odds ratio (OR) 1.07, 95% confidence interval (CI): 1.03–1.12], homeostasis model assessment for insulin resistance (OR 1.51, 95% CI: 1.15–1.98), and vomiting during the acute phase (OR 3.42, 95% CI: 1.39–8.4) were associated with PIC in patients with obesity. Vomiting during the acute phase (p for interaction = 0.033) can affect the risk of WC to PIC.ConclusionWC, insulin resistance, and vomiting during the acute phase are risk factors for PIC in patients with obesity. Reducing visceral fat and increasing insulin sensitivity in obese patients may help alleviate the burden of PIC. |
| format | Article |
| id | doaj-art-efee3d2e9d3f4ef1b31dac0bda455d37 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-efee3d2e9d3f4ef1b31dac0bda455d372025-08-20T03:28:47ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.14609291460929Post-infectious cough in patients with obesity: an observational studyYin Xian0Yuan Zhang1Xiangxin Kong2Ke Song3Department of Otorhinolaryngology, Nanchong Psychosomatic Hospital, Nanchong, ChinaDepartment of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaBackgroundUpper respiratory tract infection (URTI) can lead to post-infectious cough (PIC). It is currently unclear the current status and influencing factors of PIC in patients with obesity.MethodsData were collected from patients who visited the institution’s bariatric surgery clinic, between June and November 2022, but did not undergo surgery. Follow-up calls will be conducted in early January 2023, and whether these patients develop URTI and cough in December 2022 will be recorded. For patients with URTI and cough, the occurrence of accompanying symptoms during the course of the disease will be recorded. Then, in late February 2023, we will assess whether the cough or other accompanying symptoms have completely resolved within 8 weeks. Logistic regression analyzed the influencing factors of URTI developing into PIC in obese patients. Subgroup analyzes were used to assess interaction effects.ResultsOut of 286 study participants, 54 (18.9%) had a PIC. Waist circumference (WC) [odds ratio (OR) 1.07, 95% confidence interval (CI): 1.03–1.12], homeostasis model assessment for insulin resistance (OR 1.51, 95% CI: 1.15–1.98), and vomiting during the acute phase (OR 3.42, 95% CI: 1.39–8.4) were associated with PIC in patients with obesity. Vomiting during the acute phase (p for interaction = 0.033) can affect the risk of WC to PIC.ConclusionWC, insulin resistance, and vomiting during the acute phase are risk factors for PIC in patients with obesity. Reducing visceral fat and increasing insulin sensitivity in obese patients may help alleviate the burden of PIC.https://www.frontiersin.org/articles/10.3389/fmed.2025.1460929/fullpost-infectious coughupper respiratory tract infectioninsulin resistanceobesityinteraction |
| spellingShingle | Yin Xian Yuan Zhang Xiangxin Kong Ke Song Post-infectious cough in patients with obesity: an observational study Frontiers in Medicine post-infectious cough upper respiratory tract infection insulin resistance obesity interaction |
| title | Post-infectious cough in patients with obesity: an observational study |
| title_full | Post-infectious cough in patients with obesity: an observational study |
| title_fullStr | Post-infectious cough in patients with obesity: an observational study |
| title_full_unstemmed | Post-infectious cough in patients with obesity: an observational study |
| title_short | Post-infectious cough in patients with obesity: an observational study |
| title_sort | post infectious cough in patients with obesity an observational study |
| topic | post-infectious cough upper respiratory tract infection insulin resistance obesity interaction |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1460929/full |
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