NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA

NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA

Abstract RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers. However, the role and regulatory mechanisms of RNA m5C modification in multiple myeloma (MM) remain unclear. This study aimed to i...

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Bibliographic Details
Main Authors: Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
RNA m5C modification
NSUN2
Multiple myeloma
HIP1
Online Access:https://doi.org/10.1038/s41598-025-13695-9
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