Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients
Purpose: Evaluate the type and severity of potential drug-drug interactions and identify risk factors involved, in pediatric patients admitted in a hospital setting. Methods: Transversal retrospective analytical study was carried out with hospitalized pediatric patients from a Hospital in the West o...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957219305467 |
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| author | Fabiola Medina-Barajas Estefanía Vázquez-Méndez Edsaúl Emilio Pérez-Guerrero Virginia Aleyda Sánchez-López Iván I. Hernández-Cañaveral Real-Ornelas Gabriel A Selene G. Huerta-Olvera |
| author_facet | Fabiola Medina-Barajas Estefanía Vázquez-Méndez Edsaúl Emilio Pérez-Guerrero Virginia Aleyda Sánchez-López Iván I. Hernández-Cañaveral Real-Ornelas Gabriel A Selene G. Huerta-Olvera |
| author_sort | Fabiola Medina-Barajas |
| collection | DOAJ |
| description | Purpose: Evaluate the type and severity of potential drug-drug interactions and identify risk factors involved, in pediatric patients admitted in a hospital setting. Methods: Transversal retrospective analytical study was carried out with hospitalized pediatric patients from a Hospital in the West of Mexico, second and third level. The patients included were ≤18 years old hospitalized in the children wards; those admitted at the emergency room, neonatal intermediate and intensive therapy units were not included. Medical prescriptions were reviewed taking into consideration anthropometric characteristics, diagnosis and number of drugs prescribed to identify potential drug–drug interactions using Micromedex 2.0 database. Results: 88 patients were included, an average of 4.6 ± 2.8 of drugs were prescribed per patient. 37 subjects (42%) presented some degree of potential drug-drug interactions of which 25.5% were major and 27.7% moderate according to the software. Identified risk factors were: age ≥ 4 years (OR 1.917; 95% CI 1.081-3.399), BSA ≥ 0.8m2(OR 1.825; 95% CI 1.021–3.263), height ≥ 1 m (OR 2.556;95% CI 1.322 - 4.941), and number of prescribed medications ≥ 4 (OR 2.106;95% CI 1.248 - 3.556). Conclusion: Some of the interactions found were for the benefit of the patient, but others were considered undesirable because they altered the pharmacokinetics of some of the medications administered. Detecting in time the harmful interactions for a patient may favor the patient's safety. |
| format | Article |
| id | doaj-art-efe5aa55303448dba225fb17bcbe8558 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-efe5aa55303448dba225fb17bcbe85582025-08-20T01:55:45ZengElsevierPediatrics and Neonatology1875-95722020-06-0161327928910.1016/j.pedneo.2019.11.006Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patientsFabiola Medina-Barajas0Estefanía Vázquez-Méndez1Edsaúl Emilio Pérez-Guerrero2Virginia Aleyda Sánchez-López3Iván I. Hernández-Cañaveral4Real-Ornelas Gabriel A5Selene G. Huerta-Olvera6Pharmacy Service, Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”, 750 Salvador Quevedo y Zubieta St., 44340, Guadalajara, MexicoMedical and Pharmaceutical Biotechnology Department, Centro de Asistencia en Tecnología y Diseño del Estado de Jalisco, 800 Normalistas Av., 44270, Guadalajara, MexicoMolecular Biology and Genomics Department, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 950 Sierra Mojada St., 44340, Guadalajara, MexicoPharmacovigilance Department, Laboratorios PiSA, 1840 España Ave., 44190, Guadalajara, MexicoMicrobiology Department, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 950 Sierra Mojada St., 44340, Guadalajara, MexicoCentro integral de Medicina Ambiental y Toxicología CIMATOX S.A.S, de C.V. María Reyes 2, Guadalajara, MexicoMedical and Life Sciences Department, Centro Universitario de la Ciénega, Universidad de Guadalajara, 1115 Universidad Av., 47820, Ocotlán, Mexico; Corresponding author.Purpose: Evaluate the type and severity of potential drug-drug interactions and identify risk factors involved, in pediatric patients admitted in a hospital setting. Methods: Transversal retrospective analytical study was carried out with hospitalized pediatric patients from a Hospital in the West of Mexico, second and third level. The patients included were ≤18 years old hospitalized in the children wards; those admitted at the emergency room, neonatal intermediate and intensive therapy units were not included. Medical prescriptions were reviewed taking into consideration anthropometric characteristics, diagnosis and number of drugs prescribed to identify potential drug–drug interactions using Micromedex 2.0 database. Results: 88 patients were included, an average of 4.6 ± 2.8 of drugs were prescribed per patient. 37 subjects (42%) presented some degree of potential drug-drug interactions of which 25.5% were major and 27.7% moderate according to the software. Identified risk factors were: age ≥ 4 years (OR 1.917; 95% CI 1.081-3.399), BSA ≥ 0.8m2(OR 1.825; 95% CI 1.021–3.263), height ≥ 1 m (OR 2.556;95% CI 1.322 - 4.941), and number of prescribed medications ≥ 4 (OR 2.106;95% CI 1.248 - 3.556). Conclusion: Some of the interactions found were for the benefit of the patient, but others were considered undesirable because they altered the pharmacokinetics of some of the medications administered. Detecting in time the harmful interactions for a patient may favor the patient's safety.http://www.sciencedirect.com/science/article/pii/S1875957219305467drug-drug interactionsmedication errorspediatric patientspotential drug-drug interactions |
| spellingShingle | Fabiola Medina-Barajas Estefanía Vázquez-Méndez Edsaúl Emilio Pérez-Guerrero Virginia Aleyda Sánchez-López Iván I. Hernández-Cañaveral Real-Ornelas Gabriel A Selene G. Huerta-Olvera Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients Pediatrics and Neonatology drug-drug interactions medication errors pediatric patients potential drug-drug interactions |
| title | Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients |
| title_full | Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients |
| title_fullStr | Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients |
| title_full_unstemmed | Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients |
| title_short | Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients |
| title_sort | pilot study evaluation of potential drug drug interactions in hospitalized pediatric patients |
| topic | drug-drug interactions medication errors pediatric patients potential drug-drug interactions |
| url | http://www.sciencedirect.com/science/article/pii/S1875957219305467 |
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