Gastroduodenal form of Crohn's disease
The aim of review. To highlight modern aspects of clinical presentation, diagnostics and treatment of gastroduodenal variant of Crohn's disease (GDCD).Key points. Gastroduodenal involvement at CD is a rare clinical variant of disease and develops in less than 5,5% of cases. By the present time...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2015-10-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1062 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860167902494720 |
|---|---|
| author | I. V. Mayev D. N. Andreev Yu. A. Kucheryavy |
| author_facet | I. V. Mayev D. N. Andreev Yu. A. Kucheryavy |
| author_sort | I. V. Mayev |
| collection | DOAJ |
| description | The aim of review. To highlight modern aspects of clinical presentation, diagnostics and treatment of gastroduodenal variant of Crohn's disease (GDCD).Key points. Gastroduodenal involvement at CD is a rare clinical variant of disease and develops in less than 5,5% of cases. By the present time association of GDCD with L1007P mutation of NOD2/CARD15 gene is detected. Epigastric pain, loss of body weight, nausea and — in some cases — vomiting are the most frequent symptoms of this pathology. Endoscopy of the stomach and duodenum with histological examination are the «gold» standard of GDCD diagnostics and quite often have crucial importance in the proof of diagnosis. In difficult cases test for antiSaccharomyces cerevisiae antibodies (ASCA) can be used as additional tool of differential diagnostics. Prescription of proton pump inhibitors in combination to system corticosteroids and azathioprine/6-mercaptopurine if required can be considered as the most successful therapy. Infliximab should be considered as alternati ve drug to other forms of treatment at nonresponding cases.Conclusion. No matter that GDCD is not the common form of disease, knowledge of the clinical variant is important for its duly recognition. |
| format | Article |
| id | doaj-art-efdef238350141af9d51d7d928754426 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-efdef238350141af9d51d7d9287544262025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-10-0125559667Gastroduodenal form of Crohn's diseaseI. V. Mayev0D. N. Andreev1Yu. A. Kucheryavy2State educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Yevdokimov Moscow State University of Medicine and Dentistry», Ministry of Healthcare of the Russian FederationThe aim of review. To highlight modern aspects of clinical presentation, diagnostics and treatment of gastroduodenal variant of Crohn's disease (GDCD).Key points. Gastroduodenal involvement at CD is a rare clinical variant of disease and develops in less than 5,5% of cases. By the present time association of GDCD with L1007P mutation of NOD2/CARD15 gene is detected. Epigastric pain, loss of body weight, nausea and — in some cases — vomiting are the most frequent symptoms of this pathology. Endoscopy of the stomach and duodenum with histological examination are the «gold» standard of GDCD diagnostics and quite often have crucial importance in the proof of diagnosis. In difficult cases test for antiSaccharomyces cerevisiae antibodies (ASCA) can be used as additional tool of differential diagnostics. Prescription of proton pump inhibitors in combination to system corticosteroids and azathioprine/6-mercaptopurine if required can be considered as the most successful therapy. Infliximab should be considered as alternati ve drug to other forms of treatment at nonresponding cases.Conclusion. No matter that GDCD is not the common form of disease, knowledge of the clinical variant is important for its duly recognition.https://www.gastro-j.ru/jour/article/view/1062crohn's diseasegastroduodenal formthe stomachduodenumdiagnosticstreatment |
| spellingShingle | I. V. Mayev D. N. Andreev Yu. A. Kucheryavy Gastroduodenal form of Crohn's disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии crohn's disease gastroduodenal form the stomach duodenum diagnostics treatment |
| title | Gastroduodenal form of Crohn's disease |
| title_full | Gastroduodenal form of Crohn's disease |
| title_fullStr | Gastroduodenal form of Crohn's disease |
| title_full_unstemmed | Gastroduodenal form of Crohn's disease |
| title_short | Gastroduodenal form of Crohn's disease |
| title_sort | gastroduodenal form of crohn s disease |
| topic | crohn's disease gastroduodenal form the stomach duodenum diagnostics treatment |
| url | https://www.gastro-j.ru/jour/article/view/1062 |
| work_keys_str_mv | AT ivmayev gastroduodenalformofcrohnsdisease AT dnandreev gastroduodenalformofcrohnsdisease AT yuakucheryavy gastroduodenalformofcrohnsdisease |