Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most widespread chronic liver diseases and a serious global public health problem. Further research to identify novel risk factors associated with MASLD is urgently needed. The non-high-density lipoprotein chole...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1557751/full |
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| author | Dandan Yang Dandan Yang Hongsheng Dai Yulu Wang Jiayi Zhang Min Wei Ming Shan Ming Shan Xiaoqian Zhang |
| author_facet | Dandan Yang Dandan Yang Hongsheng Dai Yulu Wang Jiayi Zhang Min Wei Ming Shan Ming Shan Xiaoqian Zhang |
| author_sort | Dandan Yang |
| collection | DOAJ |
| description | BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most widespread chronic liver diseases and a serious global public health problem. Further research to identify novel risk factors associated with MASLD is urgently needed. The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) was identified as a novel lipid marker. The objective of this research was to assess the association between NHHR and MASLD in adults.MethodsThis cross-sectional study utilized data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES). MASLD was diagnosed in accordance with controlled attenuation parameter scores and a combination of cardiometabolic risk factors. Multivariate logistic regression analyses, in conjunction with the restricted cubic spline method, were employed to investigate the association between NHHR and MASLD risk. Furthermore, subgroup and interaction analyses were conducted.ResultsThis study included 5,269 individuals, with 2,031 individuals diagnosed with MASLD and 3,238 without MASLD. Logistic regression analyses revealed a significant positive correlation between NHHR and MASLD. After the confounding factors were adjusted, each unit rise in NHHR was correlated with a 39% higher probability of MASLD (OR = 1.39, 95% CI: 1.13–1.69). Subgroup and interaction analyses revealed that the positive correlation between NHHR and MASLD held steady regardless of age, gender, race, poverty-to-income ratio, education level, physical activity, body mass index, diabetes, hypertension, dyslipidemia and smoking status (P for interaction >0.05). In addition, a non-linear relationship with an S-shaped manner between NHHR and MASLD was found, with an inflection point at 1.59.ConclusionOur findings imply that an increasing trend in NHHR is associated with a greater risk of MASLD development. NHHR has the potential to function as an indicator for estimating the likelihood of developing MASLD. |
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| issn | 2296-861X |
| language | English |
| publishDate | 2025-03-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-efd9ba3aab494d5d862dfa2bd35b63a42025-08-20T02:17:57ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-03-011210.3389/fnut.2025.15577511557751Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver diseaseDandan Yang0Dandan Yang1Hongsheng Dai2Yulu Wang3Jiayi Zhang4Min Wei5Ming Shan6Ming Shan7Xiaoqian Zhang8Department of Gastroenterology, Affiliated Hospital of Shandong Second Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, ChinaDepartment of Gastroenterology, Affiliated Hospital of Shandong Second Medical University, Weifang, ChinaDepartment of Hepatology, The Fourth Peoples’ Hospital of Huai’an, Huai’an, ChinaDepartment of Gastroenterology, Affiliated Hospital of Shandong Second Medical University, Weifang, ChinaDepartment of Gastroenterology, Affiliated Hospital of Shandong Second Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, ChinaDepartment of Ophthalmology, Affiliated Hospital of Shandong Second Medical University, Weifang, ChinaDepartment of Gastroenterology, Affiliated Hospital of Shandong Second Medical University, Weifang, ChinaBackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most widespread chronic liver diseases and a serious global public health problem. Further research to identify novel risk factors associated with MASLD is urgently needed. The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) was identified as a novel lipid marker. The objective of this research was to assess the association between NHHR and MASLD in adults.MethodsThis cross-sectional study utilized data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES). MASLD was diagnosed in accordance with controlled attenuation parameter scores and a combination of cardiometabolic risk factors. Multivariate logistic regression analyses, in conjunction with the restricted cubic spline method, were employed to investigate the association between NHHR and MASLD risk. Furthermore, subgroup and interaction analyses were conducted.ResultsThis study included 5,269 individuals, with 2,031 individuals diagnosed with MASLD and 3,238 without MASLD. Logistic regression analyses revealed a significant positive correlation between NHHR and MASLD. After the confounding factors were adjusted, each unit rise in NHHR was correlated with a 39% higher probability of MASLD (OR = 1.39, 95% CI: 1.13–1.69). Subgroup and interaction analyses revealed that the positive correlation between NHHR and MASLD held steady regardless of age, gender, race, poverty-to-income ratio, education level, physical activity, body mass index, diabetes, hypertension, dyslipidemia and smoking status (P for interaction >0.05). In addition, a non-linear relationship with an S-shaped manner between NHHR and MASLD was found, with an inflection point at 1.59.ConclusionOur findings imply that an increasing trend in NHHR is associated with a greater risk of MASLD development. NHHR has the potential to function as an indicator for estimating the likelihood of developing MASLD.https://www.frontiersin.org/articles/10.3389/fnut.2025.1557751/fullMASLDNHHRNHANESdyslipidemiacross-sectional study |
| spellingShingle | Dandan Yang Dandan Yang Hongsheng Dai Yulu Wang Jiayi Zhang Min Wei Ming Shan Ming Shan Xiaoqian Zhang Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease Frontiers in Nutrition MASLD NHHR NHANES dyslipidemia cross-sectional study |
| title | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease |
| title_full | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease |
| title_fullStr | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease |
| title_full_unstemmed | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease |
| title_short | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease |
| title_sort | association between the non high density lipoprotein cholesterol to high density lipoprotein cholesterol ratio and metabolic dysfunction associated steatotic liver disease |
| topic | MASLD NHHR NHANES dyslipidemia cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1557751/full |
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