Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore
Abstract Sensory circuits are organized in parallel, e.g. parallel streams relay feedforward visual information from retina to cortex. Corticogeniculate (CG) feedback is also organized in parallel; however, stream-specific influences of CG feedback remained unresolved. We utilized optogenetics to ma...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58667-9 |
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| author | Sabrina Mai Allison J. Murphy J. Michael Hasse Farran Briggs |
| author_facet | Sabrina Mai Allison J. Murphy J. Michael Hasse Farran Briggs |
| author_sort | Sabrina Mai |
| collection | DOAJ |
| description | Abstract Sensory circuits are organized in parallel, e.g. parallel streams relay feedforward visual information from retina to cortex. Corticogeniculate (CG) feedback is also organized in parallel; however, stream-specific influences of CG feedback remained unresolved. We utilized optogenetics to manipulate CG feedback in monkeys while recording geniculate responses to a comprehensive set of visual stimuli designed to probe stream-specific responses. Here we show that CG feedback improved the spatial resolution of magnocellular, but not parvocellular neurons. Optogenetically enhancing CG feedback increased extraclassical surround suppression, shrunk classical receptive fields, and increased preferred spatial frequencies among magnocellular neurons. Optogenetically suppressing CG feedback reduced surround suppression. Enhancing CG feedback in female ferrets revealed similar stream-specific effects in geniculate Y, but not X neurons. Furthermore, optogenetically enhancing CG feedback improved temporal response precision across neuronal types. These results support dual functional roles for CG feedback in enhancing spatial resolution in a stream-specific manner and improving temporal precision broadly. |
| format | Article |
| id | doaj-art-efd52dabda994b4981f5314042cece6a |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-efd52dabda994b4981f5314042cece6a2025-08-20T03:10:13ZengNature PortfolioNature Communications2041-17232025-04-0116111910.1038/s41467-025-58667-9Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivoreSabrina Mai0Allison J. Murphy1J. Michael Hasse2Farran Briggs3Neuroscience Graduate Program, University of RochesterNeuroscience Graduate Program, University of RochesterCenter for Neural Science, New York UniversityNeuroscience Graduate Program, University of RochesterAbstract Sensory circuits are organized in parallel, e.g. parallel streams relay feedforward visual information from retina to cortex. Corticogeniculate (CG) feedback is also organized in parallel; however, stream-specific influences of CG feedback remained unresolved. We utilized optogenetics to manipulate CG feedback in monkeys while recording geniculate responses to a comprehensive set of visual stimuli designed to probe stream-specific responses. Here we show that CG feedback improved the spatial resolution of magnocellular, but not parvocellular neurons. Optogenetically enhancing CG feedback increased extraclassical surround suppression, shrunk classical receptive fields, and increased preferred spatial frequencies among magnocellular neurons. Optogenetically suppressing CG feedback reduced surround suppression. Enhancing CG feedback in female ferrets revealed similar stream-specific effects in geniculate Y, but not X neurons. Furthermore, optogenetically enhancing CG feedback improved temporal response precision across neuronal types. These results support dual functional roles for CG feedback in enhancing spatial resolution in a stream-specific manner and improving temporal precision broadly.https://doi.org/10.1038/s41467-025-58667-9 |
| spellingShingle | Sabrina Mai Allison J. Murphy J. Michael Hasse Farran Briggs Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore Nature Communications |
| title | Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore |
| title_full | Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore |
| title_fullStr | Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore |
| title_full_unstemmed | Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore |
| title_short | Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore |
| title_sort | dual parallel stream specific and generalized effects of corticogeniculate feedback on lgn neurons in primate and carnivore |
| url | https://doi.org/10.1038/s41467-025-58667-9 |
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