Current Role of Minimally Invasive Radical Cholecystectomy for Gallbladder Cancer
Background. For Tis and T1a gallbladder cancer (GbC), laparoscopic cholecystectomy can provide similar survival outcomes compared to open cholecystectomy. However, for patients affected by resectable T1b or more advanced GbC, open approach radical cholecystectomy (RC), consisting in gallbladder live...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/7684915 |
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| author | Giuseppe Zimmitti Alberto Manzoni Francesca Guerini Marco Ramera Paola Bertocchi Francesca Aroldi Alberto Zaniboni Edoardo Rosso |
| author_facet | Giuseppe Zimmitti Alberto Manzoni Francesca Guerini Marco Ramera Paola Bertocchi Francesca Aroldi Alberto Zaniboni Edoardo Rosso |
| author_sort | Giuseppe Zimmitti |
| collection | DOAJ |
| description | Background. For Tis and T1a gallbladder cancer (GbC), laparoscopic cholecystectomy can provide similar survival outcomes compared to open cholecystectomy. However, for patients affected by resectable T1b or more advanced GbC, open approach radical cholecystectomy (RC), consisting in gallbladder liver bed resection or segment 4b-5 bisegmentectomy, with locoregional lymphadenectomy, is considered the gold standard while minimally invasive RC (MiRC) is skeptically considered. Aim. To analyze current literature on perioperative and oncologic outcomes of MiRC for patients affected by GbC. Methods. A Medline review of published articles until June 2016 concerning MiRC for GbC was performed. Results. Data relevant for this review were presented in 13 articles, including 152 patients undergoing an attempt of MiRC for GbC. No randomized clinical trial was found. The approach was laparoscopic in 147 patients and robotic in five. Conversion was required in 15 (10%) patients. Postoperative complications rate was 10% with no mortality. Long-term survival outcomes were reported by 11 studies, two of them showing similar oncologic results when comparing MiRC with matched open RC. Conclusions. Although randomized clinical trials are still lacking and only descriptive studies reporting on limited number of patients are available, current literature seems suggesting that when performed at highly specialized centers, MiRC for GbC is safe and feasible and has oncologic outcomes comparable to open RC. |
| format | Article |
| id | doaj-art-efd14f308fca4747bad953d9eb2bd228 |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-efd14f308fca4747bad953d9eb2bd2282025-08-20T03:06:27ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/76849157684915Current Role of Minimally Invasive Radical Cholecystectomy for Gallbladder CancerGiuseppe Zimmitti0Alberto Manzoni1Francesca Guerini2Marco Ramera3Paola Bertocchi4Francesca Aroldi5Alberto Zaniboni6Edoardo Rosso7Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Via Bissolati n 57, Brescia, ItalyDepartment of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Via Bissolati n 57, Brescia, ItalyDepartment of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Via Bissolati n 57, Brescia, ItalyDepartment of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Via Bissolati n 57, Brescia, ItalyDepartment of Oncology, Istituto Ospedaliero Fondazione Poliambulanza, Via Bissolati n 57, Brescia, ItalyDepartment of Oncology, Istituto Ospedaliero Fondazione Poliambulanza, Via Bissolati n 57, Brescia, ItalyDepartment of Oncology, Istituto Ospedaliero Fondazione Poliambulanza, Via Bissolati n 57, Brescia, ItalyDepartment of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Via Bissolati n 57, Brescia, ItalyBackground. For Tis and T1a gallbladder cancer (GbC), laparoscopic cholecystectomy can provide similar survival outcomes compared to open cholecystectomy. However, for patients affected by resectable T1b or more advanced GbC, open approach radical cholecystectomy (RC), consisting in gallbladder liver bed resection or segment 4b-5 bisegmentectomy, with locoregional lymphadenectomy, is considered the gold standard while minimally invasive RC (MiRC) is skeptically considered. Aim. To analyze current literature on perioperative and oncologic outcomes of MiRC for patients affected by GbC. Methods. A Medline review of published articles until June 2016 concerning MiRC for GbC was performed. Results. Data relevant for this review were presented in 13 articles, including 152 patients undergoing an attempt of MiRC for GbC. No randomized clinical trial was found. The approach was laparoscopic in 147 patients and robotic in five. Conversion was required in 15 (10%) patients. Postoperative complications rate was 10% with no mortality. Long-term survival outcomes were reported by 11 studies, two of them showing similar oncologic results when comparing MiRC with matched open RC. Conclusions. Although randomized clinical trials are still lacking and only descriptive studies reporting on limited number of patients are available, current literature seems suggesting that when performed at highly specialized centers, MiRC for GbC is safe and feasible and has oncologic outcomes comparable to open RC.http://dx.doi.org/10.1155/2016/7684915 |
| spellingShingle | Giuseppe Zimmitti Alberto Manzoni Francesca Guerini Marco Ramera Paola Bertocchi Francesca Aroldi Alberto Zaniboni Edoardo Rosso Current Role of Minimally Invasive Radical Cholecystectomy for Gallbladder Cancer Gastroenterology Research and Practice |
| title | Current Role of Minimally Invasive Radical Cholecystectomy for Gallbladder Cancer |
| title_full | Current Role of Minimally Invasive Radical Cholecystectomy for Gallbladder Cancer |
| title_fullStr | Current Role of Minimally Invasive Radical Cholecystectomy for Gallbladder Cancer |
| title_full_unstemmed | Current Role of Minimally Invasive Radical Cholecystectomy for Gallbladder Cancer |
| title_short | Current Role of Minimally Invasive Radical Cholecystectomy for Gallbladder Cancer |
| title_sort | current role of minimally invasive radical cholecystectomy for gallbladder cancer |
| url | http://dx.doi.org/10.1155/2016/7684915 |
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