Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics studyKey Message
Background: Many studies reported the influence of infants' gut microbiota on atopic dermatitis (AD) postnatally, yet the role of maternal gut microbiota and plasma metabolites in infants’ AD remains largely unexplored. Methods: Sixty-three pregnant mother-infants were enrolled and followed aft...
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Elsevier
2025-01-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455124001492 |
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| author | Bingqian Du, MA.Sc Aga Shama, BA.Sc Yi Zhang, BA.Sc Baolan Chen, MA.Sc Yongqi Bu, BA.Sc Pei-an Chen, MA.Sc Chuzhi Lin, BA.Sc Jie Liu, MA.Sc Juan Zheng, MA.Sc Zhenjun Li, MD, PhD Qingsong Chen, PhD Yu Sun, PhD Xi Fu, PhD |
| author_facet | Bingqian Du, MA.Sc Aga Shama, BA.Sc Yi Zhang, BA.Sc Baolan Chen, MA.Sc Yongqi Bu, BA.Sc Pei-an Chen, MA.Sc Chuzhi Lin, BA.Sc Jie Liu, MA.Sc Juan Zheng, MA.Sc Zhenjun Li, MD, PhD Qingsong Chen, PhD Yu Sun, PhD Xi Fu, PhD |
| author_sort | Bingqian Du, MA.Sc |
| collection | DOAJ |
| description | Background: Many studies reported the influence of infants' gut microbiota on atopic dermatitis (AD) postnatally, yet the role of maternal gut microbiota and plasma metabolites in infants’ AD remains largely unexplored. Methods: Sixty-three pregnant mother-infants were enrolled and followed after childbirth in Guangzhou, China. Demographic information, maternal stool and plasma samples, and records for infants’ AD were collected. Maternal gut microbiota/metabolome and plasma metabolome were profiled using shotgun metagenomics and non-targeted metabolomics. Logistic regression and multi-omics analysis were used to explore characteristic maternal gut microbiota in the AD and health groups. Results: The α-diversity of maternal gut microbiota in health group was significantly higher than AD group (Shannon diversity P = 0.02, Simpson diversity P = 0.04). Short-chain fatty acids (SCFAs) producing microorganisms, including Faecalibacterium, Roseburia, Butyricicoccus, and Ruminococcus, as well as the abundance of phenylalanine, tyrosine, and tryptophan biosynthesis pathway, were enriched in health group (LDA>2 and P < 0.05). Virulent factors (VFs) involved in immune modulation were enriched in the health group, while VFs involving in adhesin were enriched in the AD group (P < 0.05). Metabolomic analysis showed that a polyunsaturated fatty acid/linoleic acid, 13S-hydroxyoctadecadienoic, were negatively associated with AD in both the gut and plasma samples (FDR<0.05). Several other linoleic acids and flavonoids were negatively associated with AD (FDR<0.05). Neural network analysis revealed that microorganisms enriched in health group may produce these protective fatty acids. Conclusions: Our findings show that maternal gut microorganisms/metabolites and plasma metabolites during pregnancy impact subsequent pathogenesis of infants AD. This illuminates new strategies against early AD in offspring. |
| format | Article |
| id | doaj-art-efd0d9139e63477fa32e8c8d168863e3 |
| institution | Kabale University |
| issn | 1939-4551 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | World Allergy Organization Journal |
| spelling | doaj-art-efd0d9139e63477fa32e8c8d168863e32025-01-17T04:49:16ZengElsevierWorld Allergy Organization Journal1939-45512025-01-01181101017Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics studyKey MessageBingqian Du, MA.Sc0Aga Shama, BA.Sc1Yi Zhang, BA.Sc2Baolan Chen, MA.Sc3Yongqi Bu, BA.Sc4Pei-an Chen, MA.Sc5Chuzhi Lin, BA.Sc6Jie Liu, MA.Sc7Juan Zheng, MA.Sc8Zhenjun Li, MD, PhD9Qingsong Chen, PhD10Yu Sun, PhD11Xi Fu, PhD12Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102200, PR ChinaGuangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR ChinaGuangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR ChinaGuangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR ChinaGuangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR ChinaGuangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR ChinaGuangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR ChinaMaternity and Child Health Hospital of Baiyun District, Guangzhou, 510400, Guangdong, PR ChinaMaternity and Child Health Hospital of Baiyun District, Guangzhou, 510400, Guangdong, PR ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102200, PR ChinaGuangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, 510642, Guangdong, PR China; Corresponding author.Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR China; Corresponding author.Background: Many studies reported the influence of infants' gut microbiota on atopic dermatitis (AD) postnatally, yet the role of maternal gut microbiota and plasma metabolites in infants’ AD remains largely unexplored. Methods: Sixty-three pregnant mother-infants were enrolled and followed after childbirth in Guangzhou, China. Demographic information, maternal stool and plasma samples, and records for infants’ AD were collected. Maternal gut microbiota/metabolome and plasma metabolome were profiled using shotgun metagenomics and non-targeted metabolomics. Logistic regression and multi-omics analysis were used to explore characteristic maternal gut microbiota in the AD and health groups. Results: The α-diversity of maternal gut microbiota in health group was significantly higher than AD group (Shannon diversity P = 0.02, Simpson diversity P = 0.04). Short-chain fatty acids (SCFAs) producing microorganisms, including Faecalibacterium, Roseburia, Butyricicoccus, and Ruminococcus, as well as the abundance of phenylalanine, tyrosine, and tryptophan biosynthesis pathway, were enriched in health group (LDA>2 and P < 0.05). Virulent factors (VFs) involved in immune modulation were enriched in the health group, while VFs involving in adhesin were enriched in the AD group (P < 0.05). Metabolomic analysis showed that a polyunsaturated fatty acid/linoleic acid, 13S-hydroxyoctadecadienoic, were negatively associated with AD in both the gut and plasma samples (FDR<0.05). Several other linoleic acids and flavonoids were negatively associated with AD (FDR<0.05). Neural network analysis revealed that microorganisms enriched in health group may produce these protective fatty acids. Conclusions: Our findings show that maternal gut microorganisms/metabolites and plasma metabolites during pregnancy impact subsequent pathogenesis of infants AD. This illuminates new strategies against early AD in offspring.http://www.sciencedirect.com/science/article/pii/S1939455124001492Fatty acidsMetabolomeVirulent factorsFlavonoidsAtopic dermatitis |
| spellingShingle | Bingqian Du, MA.Sc Aga Shama, BA.Sc Yi Zhang, BA.Sc Baolan Chen, MA.Sc Yongqi Bu, BA.Sc Pei-an Chen, MA.Sc Chuzhi Lin, BA.Sc Jie Liu, MA.Sc Juan Zheng, MA.Sc Zhenjun Li, MD, PhD Qingsong Chen, PhD Yu Sun, PhD Xi Fu, PhD Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics studyKey Message World Allergy Organization Journal Fatty acids Metabolome Virulent factors Flavonoids Atopic dermatitis |
| title | Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics studyKey Message |
| title_full | Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics studyKey Message |
| title_fullStr | Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics studyKey Message |
| title_full_unstemmed | Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics studyKey Message |
| title_short | Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics studyKey Message |
| title_sort | gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis a multi omics studykey message |
| topic | Fatty acids Metabolome Virulent factors Flavonoids Atopic dermatitis |
| url | http://www.sciencedirect.com/science/article/pii/S1939455124001492 |
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