Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy
γδ T cells, a type of specialized T cell, differ from alpha-beta T cells due to the presence of γ and δ chain surface T cell receptors. These receptors allow them to directly recognize and bind antigenic molecules without the requirement of attachment to MHC or APC antigen presentation. Given their...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1554541/full |
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| author | Lu Wang Jiaqi Li Yaping Xuan Jinrui Zhang Xiao Wang Wei Hu Wei Hu Wei Hu Lei Xiu |
| author_facet | Lu Wang Jiaqi Li Yaping Xuan Jinrui Zhang Xiao Wang Wei Hu Wei Hu Wei Hu Lei Xiu |
| author_sort | Lu Wang |
| collection | DOAJ |
| description | γδ T cells, a type of specialized T cell, differ from alpha-beta T cells due to the presence of γ and δ chain surface T cell receptors. These receptors allow them to directly recognize and bind antigenic molecules without the requirement of attachment to MHC or APC antigen presentation. Given their intrinsic properties and functional versatility, γδ T cells are under intensive investigation as carriers for chimeric antigen receptor (CAR) in the context of cancer therapy. In this regard, γδ CAR-T cells have demonstrated great potential to overcome the limitations of antigen recognition with the help of dual antigen identification mechanisms. However, there are still technological challenges that need to be addressed. This discussion focuses on the research status and future development prospects of γδ T cells and γδ CAR-T cells, aiming to provide valuable insights for the follow-up research and practical application of γδ CAR-T cells. |
| format | Article |
| id | doaj-art-efc92c1203f74d9aac17a057a3db044e |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-efc92c1203f74d9aac17a057a3db044e2025-08-20T02:20:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15545411554541Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapyLu Wang0Jiaqi Li1Yaping Xuan2Jinrui Zhang3Xiao Wang4Wei Hu5Wei Hu6Wei Hu7Lei Xiu8State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, ChinaState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, ChinaState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, ChinaState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, ChinaState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, ChinaState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, ChinaState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, ChinaDepartment of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, ChinaState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, Chinaγδ T cells, a type of specialized T cell, differ from alpha-beta T cells due to the presence of γ and δ chain surface T cell receptors. These receptors allow them to directly recognize and bind antigenic molecules without the requirement of attachment to MHC or APC antigen presentation. Given their intrinsic properties and functional versatility, γδ T cells are under intensive investigation as carriers for chimeric antigen receptor (CAR) in the context of cancer therapy. In this regard, γδ CAR-T cells have demonstrated great potential to overcome the limitations of antigen recognition with the help of dual antigen identification mechanisms. However, there are still technological challenges that need to be addressed. This discussion focuses on the research status and future development prospects of γδ T cells and γδ CAR-T cells, aiming to provide valuable insights for the follow-up research and practical application of γδ CAR-T cells.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1554541/fullγδ T cellsγδ CAR-T cellscancer therapyanti-tumor responsespro-tumor response |
| spellingShingle | Lu Wang Jiaqi Li Yaping Xuan Jinrui Zhang Xiao Wang Wei Hu Wei Hu Wei Hu Lei Xiu Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy Frontiers in Immunology γδ T cells γδ CAR-T cells cancer therapy anti-tumor responses pro-tumor response |
| title | Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy |
| title_full | Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy |
| title_fullStr | Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy |
| title_full_unstemmed | Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy |
| title_short | Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy |
| title_sort | prospects for γδ t cells and chimeric antigen receptor γδ t cells in cancer immunotherapy |
| topic | γδ T cells γδ CAR-T cells cancer therapy anti-tumor responses pro-tumor response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1554541/full |
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