Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated Cases
ABSTRACT The corrected QT (QTc) interval is a critical marker for assessing proarrhythmic potential in drug development, while the corrected JT (JTc) interval provides specific insight into ventricular repolarization. This study quantitatively analyzed the relationships of QTc and JTc intervals with...
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Wiley
2025-06-01
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| Series: | Clinical and Translational Science |
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| Online Access: | https://doi.org/10.1111/cts.70263 |
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| author | Eunwoo Kim Hyun Young Lee Young‐Min Ye Anhye Kim |
| author_facet | Eunwoo Kim Hyun Young Lee Young‐Min Ye Anhye Kim |
| author_sort | Eunwoo Kim |
| collection | DOAJ |
| description | ABSTRACT The corrected QT (QTc) interval is a critical marker for assessing proarrhythmic potential in drug development, while the corrected JT (JTc) interval provides specific insight into ventricular repolarization. This study quantitatively analyzed the relationships of QTc and JTc intervals with age and sex utilizing a large real‐world dataset of hospital‐based controls and moxifloxacin‐treated patients. This retrospective study analyzed 1,039,550 electrocardiograms and associated clinical data extracted from a previously constructed electrocardiogram database, categorizing cases as hospital‐based controls (n = 119,882) or moxifloxacin‐treated (n = 1586) based on predefined criteria. We observed a general trend of QTc and JTc interval prolongation with age in both groups, with moxifloxacin‐treated cases showing longer QTc and JTc intervals than hospital‐based controls. Multiple linear regression analysis indicated that in hospital‐based controls, QTc and JTc intervals increased with age, with males exhibiting shorter intervals than females. Meanwhile, in moxifloxacin‐treated cases, QTc and JTc intervals showed similar age‐dependent increases, although no significant sex differences were observed in the QTc interval. Therefore, this study quantified the effects of age and sex on QTc and JTc intervals in hospital‐based controls and highlighted similar age‐related trends in moxifloxacin‐treated cases, underscoring the relevance of age and sex as key factors in interpreting QTc and JTc intervals across diverse clinical contexts. |
| format | Article |
| id | doaj-art-efc7400911b44360a3fee39f71f144e4 |
| institution | Kabale University |
| issn | 1752-8054 1752-8062 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
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| series | Clinical and Translational Science |
| spelling | doaj-art-efc7400911b44360a3fee39f71f144e42025-08-20T03:29:52ZengWileyClinical and Translational Science1752-80541752-80622025-06-01186n/an/a10.1111/cts.70263Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated CasesEunwoo Kim0Hyun Young Lee1Young‐Min Ye2Anhye Kim3Department of Clinical Pharmacology & Therapeutics, CHA University Bundang Medical Center Seongnam‐si Republic of KoreaClinical Trial Center Ajou University Hospital Suwon Republic of KoreaDepartment of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Republic of KoreaDepartment of Clinical Pharmacology & Therapeutics, CHA University Bundang Medical Center Seongnam‐si Republic of KoreaABSTRACT The corrected QT (QTc) interval is a critical marker for assessing proarrhythmic potential in drug development, while the corrected JT (JTc) interval provides specific insight into ventricular repolarization. This study quantitatively analyzed the relationships of QTc and JTc intervals with age and sex utilizing a large real‐world dataset of hospital‐based controls and moxifloxacin‐treated patients. This retrospective study analyzed 1,039,550 electrocardiograms and associated clinical data extracted from a previously constructed electrocardiogram database, categorizing cases as hospital‐based controls (n = 119,882) or moxifloxacin‐treated (n = 1586) based on predefined criteria. We observed a general trend of QTc and JTc interval prolongation with age in both groups, with moxifloxacin‐treated cases showing longer QTc and JTc intervals than hospital‐based controls. Multiple linear regression analysis indicated that in hospital‐based controls, QTc and JTc intervals increased with age, with males exhibiting shorter intervals than females. Meanwhile, in moxifloxacin‐treated cases, QTc and JTc intervals showed similar age‐dependent increases, although no significant sex differences were observed in the QTc interval. Therefore, this study quantified the effects of age and sex on QTc and JTc intervals in hospital‐based controls and highlighted similar age‐related trends in moxifloxacin‐treated cases, underscoring the relevance of age and sex as key factors in interpreting QTc and JTc intervals across diverse clinical contexts.https://doi.org/10.1111/cts.70263age effectelectrocardiogramJTc intervalmoxifloxacinQTc interval |
| spellingShingle | Eunwoo Kim Hyun Young Lee Young‐Min Ye Anhye Kim Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated Cases Clinical and Translational Science age effect electrocardiogram JTc interval moxifloxacin QTc interval |
| title | Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated Cases |
| title_full | Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated Cases |
| title_fullStr | Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated Cases |
| title_full_unstemmed | Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated Cases |
| title_short | Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated Cases |
| title_sort | large scale analysis of age and sex effects on corrected qt and jt intervals insights from hospital based controls and moxifloxacin treated cases |
| topic | age effect electrocardiogram JTc interval moxifloxacin QTc interval |
| url | https://doi.org/10.1111/cts.70263 |
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