Deletion of succinic semialdehyde dehydrogenase sad and chromosomal expression of phosphoenolpyruvate carboxylase as metabolic requirements for improved production of 2,4-dihydroxybutyric acid via malyl-P pathway using E. coli

Deletion of succinic semialdehyde dehydrogenase sad and chromosomal expression of phosphoenolpyruvate carboxylase as metabolic requirements for improved production of 2,4-dihydroxybutyric acid via malyl-P pathway using E. coli

The fermentative production of the functional precursor 2,4-dihydroxybutyrate (DHB) enables sustainable synthesis of the methionine analogue hydroxy-4-(methylthio) butyrate, which is currently still produced from fossil fuels. In this work, we aimed to optimize the aerobic production of DHB from glu...

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Bibliographic Details
Main Authors: T. A. Stefanie Nguyen, Ceren Alkim, Nadine Ihle, Thomas Walther, Cláudio J. R. Frazão
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
strain engineering
synthetic metabolic pathway
2,4-dihydroxybutyric acid
malyl phosphate pathway
succinic semialdehyde dehydrogenase
phosphoenolpyruvate carboxylase
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1589489/full
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