The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases
Scoparone (SCO), also known as 6,7-Dimethoxycoumarin, is a naturally occurring bioactive ingredient originally derived from Chinese herb Artemisiae Scopariae Herba (Yin-Chen-Hao). Previous studies have shown that it is effective in treating some of the liver diseases. Beyond its hepatoprotective eff...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518886/full |
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| author | Feifei Qiu Jingru Lin Xiaofei Huang Bin Yang Weihui Lu Weihui Lu Zhenhua Dai Zhenhua Dai |
| author_facet | Feifei Qiu Jingru Lin Xiaofei Huang Bin Yang Weihui Lu Weihui Lu Zhenhua Dai Zhenhua Dai |
| author_sort | Feifei Qiu |
| collection | DOAJ |
| description | Scoparone (SCO), also known as 6,7-Dimethoxycoumarin, is a naturally occurring bioactive ingredient originally derived from Chinese herb Artemisiae Scopariae Herba (Yin-Chen-Hao). Previous studies have shown that it is effective in treating some of the liver diseases. Beyond its hepatoprotective effects, an expanding body of research has underscored the immunoregulatory properties of SCO, indicating its potential therapeutic benefits for autoimmune and other inflammatory diseases. Over the past decade, significant advances have been made in understanding the mechanistic insights into its effects on immune-mediated diseases as well as liver diseases. SCO has an impact on various immune cells, including mast cells, monocytes, macrophages, neutrophils and T cells, and affects a broad range of intracellular signaling pathways, including TLR4/Myd88/NFκB, TGFβR/Smad3 and JNK/Sab/SHP-1 etc. Therefore, this review not only summarizes the immunomodulatory and therapeutic effects of SCO on immune-based inflammatory diseases (IMIDs), such as inflammatory bowel disease, osteoarthritis, allergic rhinitis, acute lung injury, type 1 diabetes and neuroinflammatory diseases etc., but also provides a comprehensive summary of its therapeutic effects on hepatic diseases, including non-alcoholic steatohepatitis, fulminant hepatic failure and hepatic fibrosis. In this review, we also include the broad impacts of SCO on intracellular signaling pathways, such as TLR4/Myd88/NFκB, TGFβR/Smad3, Nrf2/P38, JAK2/STAT3 and JNK/Sab/SHP-1 etc. Further researches on SCO may help understand its in-depth mechanisms of action and pave the way for the development of novel drugs to prevent and treat various immune-mediated inflammatory disorders as well as hepatic diseases, thereby significantly advancing its innovations and pharmaceutical applications. |
| format | Article |
| id | doaj-art-efc366fe09074bf292a7518df4cc2753 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-efc366fe09074bf292a7518df4cc27532025-01-31T05:10:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15188861518886The immunoregulatory effects of scoparone on immune-mediated inflammatory diseasesFeifei Qiu0Jingru Lin1Xiaofei Huang2Bin Yang3Weihui Lu4Weihui Lu5Zhenhua Dai6Zhenhua Dai7Section of Immunology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaSection of Immunology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaSection of Immunology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Cardiovascular Sciences, College of Life Sciences University of Leicester, Leicester, United KingdomSection of Immunology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaSection of Immunology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaScoparone (SCO), also known as 6,7-Dimethoxycoumarin, is a naturally occurring bioactive ingredient originally derived from Chinese herb Artemisiae Scopariae Herba (Yin-Chen-Hao). Previous studies have shown that it is effective in treating some of the liver diseases. Beyond its hepatoprotective effects, an expanding body of research has underscored the immunoregulatory properties of SCO, indicating its potential therapeutic benefits for autoimmune and other inflammatory diseases. Over the past decade, significant advances have been made in understanding the mechanistic insights into its effects on immune-mediated diseases as well as liver diseases. SCO has an impact on various immune cells, including mast cells, monocytes, macrophages, neutrophils and T cells, and affects a broad range of intracellular signaling pathways, including TLR4/Myd88/NFκB, TGFβR/Smad3 and JNK/Sab/SHP-1 etc. Therefore, this review not only summarizes the immunomodulatory and therapeutic effects of SCO on immune-based inflammatory diseases (IMIDs), such as inflammatory bowel disease, osteoarthritis, allergic rhinitis, acute lung injury, type 1 diabetes and neuroinflammatory diseases etc., but also provides a comprehensive summary of its therapeutic effects on hepatic diseases, including non-alcoholic steatohepatitis, fulminant hepatic failure and hepatic fibrosis. In this review, we also include the broad impacts of SCO on intracellular signaling pathways, such as TLR4/Myd88/NFκB, TGFβR/Smad3, Nrf2/P38, JAK2/STAT3 and JNK/Sab/SHP-1 etc. Further researches on SCO may help understand its in-depth mechanisms of action and pave the way for the development of novel drugs to prevent and treat various immune-mediated inflammatory disorders as well as hepatic diseases, thereby significantly advancing its innovations and pharmaceutical applications.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518886/fullinflammatory diseaseimmunoregulationliver diseasescoparonesignaling pathway |
| spellingShingle | Feifei Qiu Jingru Lin Xiaofei Huang Bin Yang Weihui Lu Weihui Lu Zhenhua Dai Zhenhua Dai The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases Frontiers in Immunology inflammatory disease immunoregulation liver disease scoparone signaling pathway |
| title | The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases |
| title_full | The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases |
| title_fullStr | The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases |
| title_full_unstemmed | The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases |
| title_short | The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases |
| title_sort | immunoregulatory effects of scoparone on immune mediated inflammatory diseases |
| topic | inflammatory disease immunoregulation liver disease scoparone signaling pathway |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518886/full |
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