Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharides
Polygonatum cyrtonema Hua polysaccharides (PCP) have beneficial effects on lipid metabolism and oxidative stress. Here, PCP extraction was optimized using response surface methodology (RSM), and the antioxidant and lipid-lowering effects of its main component, PCP1, were evaluated in vitro. The maxi...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | CyTA - Journal of Food |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2024.2310071 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850112803694706688 |
|---|---|
| author | Jin Zuo Wei Liu Lei Tian Mengyan Wang Chunyan Liu Min Wang Zheng Fang Jun Han Guodong Wang Qin Yin |
| author_facet | Jin Zuo Wei Liu Lei Tian Mengyan Wang Chunyan Liu Min Wang Zheng Fang Jun Han Guodong Wang Qin Yin |
| author_sort | Jin Zuo |
| collection | DOAJ |
| description | Polygonatum cyrtonema Hua polysaccharides (PCP) have beneficial effects on lipid metabolism and oxidative stress. Here, PCP extraction was optimized using response surface methodology (RSM), and the antioxidant and lipid-lowering effects of its main component, PCP1, were evaluated in vitro. The maximum PCP yield was 11.05% at an extraction temperature was 72°C, liquid-to-solid ratio of 21, extraction time of 96 min, and two extraction rounds. PCP1 was purified by column chromatography and showed significant scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl, and 2, 2'-azino-bis 3-ethylbenzthiazo-line-6-sulfonic acid (ABTS) radicals at concentration of 0.2–1.0 mg/mL. At a concentration of 200 [Formula: see text]g/mL, PCP1 significantly improved lipid disorder and damage induced by palmitic acid in HepG2 cells. These results show that PCP has potent antioxidant and lipid-lowering effects in vitro; moreover, the PCP extraction rate is significantly increased using RSM. Therefore, PCP is an effective antioxidant and lipid-lowering product with potential medicinal applications. |
| format | Article |
| id | doaj-art-efc33a23b0564617b69945dbd347c4fb |
| institution | OA Journals |
| issn | 1947-6337 1947-6345 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj-art-efc33a23b0564617b69945dbd347c4fb2025-08-20T02:37:17ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452024-12-0122110.1080/19476337.2024.2310071Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharidesJin Zuo0Wei Liu1Lei Tian2Mengyan Wang3Chunyan Liu4Min Wang5Zheng Fang6Jun Han7Guodong Wang8Qin Yin9Department of Pharmacy, the Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaSchool of Pharmacy, Wannan Medical College, Wuhu, ChinaSchool of Pharmacy, Wannan Medical College, Wuhu, ChinaSchool of Pharmacy, Wannan Medical College, Wuhu, ChinaSchool of Pharmacy, Wannan Medical College, Wuhu, ChinaInstitute of Medical Technology, Wuhu Medical and Health School, Wuhu, ChinaSchool of Pharmacy, Wannan Medical College, Wuhu, ChinaSchool of Pharmacy, Wannan Medical College, Wuhu, ChinaSchool of Pharmacy, Wannan Medical College, Wuhu, ChinaDepartment of Pharmacy, the Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaPolygonatum cyrtonema Hua polysaccharides (PCP) have beneficial effects on lipid metabolism and oxidative stress. Here, PCP extraction was optimized using response surface methodology (RSM), and the antioxidant and lipid-lowering effects of its main component, PCP1, were evaluated in vitro. The maximum PCP yield was 11.05% at an extraction temperature was 72°C, liquid-to-solid ratio of 21, extraction time of 96 min, and two extraction rounds. PCP1 was purified by column chromatography and showed significant scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl, and 2, 2'-azino-bis 3-ethylbenzthiazo-line-6-sulfonic acid (ABTS) radicals at concentration of 0.2–1.0 mg/mL. At a concentration of 200 [Formula: see text]g/mL, PCP1 significantly improved lipid disorder and damage induced by palmitic acid in HepG2 cells. These results show that PCP has potent antioxidant and lipid-lowering effects in vitro; moreover, the PCP extraction rate is significantly increased using RSM. Therefore, PCP is an effective antioxidant and lipid-lowering product with potential medicinal applications.https://www.tandfonline.com/doi/10.1080/19476337.2024.2310071Polygonatum cyrtonema Huapolysaccharideextraction optimizationantioxidant activitylipid-lowering effect |
| spellingShingle | Jin Zuo Wei Liu Lei Tian Mengyan Wang Chunyan Liu Min Wang Zheng Fang Jun Han Guodong Wang Qin Yin Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharides CyTA - Journal of Food Polygonatum cyrtonema Hua polysaccharide extraction optimization antioxidant activity lipid-lowering effect |
| title | Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharides |
| title_full | Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharides |
| title_fullStr | Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharides |
| title_full_unstemmed | Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharides |
| title_short | Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharides |
| title_sort | extraction optimization antioxidants and lipid lowering activities of polygonatum cyrtonema hua polysaccharides |
| topic | Polygonatum cyrtonema Hua polysaccharide extraction optimization antioxidant activity lipid-lowering effect |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2024.2310071 |
| work_keys_str_mv | AT jinzuo extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT weiliu extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT leitian extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT mengyanwang extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT chunyanliu extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT minwang extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT zhengfang extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT junhan extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT guodongwang extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides AT qinyin extractionoptimizationantioxidantsandlipidloweringactivitiesofpolygonatumcyrtonemahuapolysaccharides |