Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning
Acute carbon monoxide poisoning (ACOP) is a significant contributor to acute poisoning incidents worldwide, with numerous patients suffering from cognitive impairment. Growing evidence indicates that patients with ACOP exhibit both disrupted functional connectivity and corpus callosum (CC) degenerat...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025001881 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849331451486535680 |
|---|---|
| author | Mingyue Ma Yu Shang Xiaoying Lin Wenxuan Han Yihao Peng Shenghai Wang Chen Niu Haining Li Ming Zhang |
| author_facet | Mingyue Ma Yu Shang Xiaoying Lin Wenxuan Han Yihao Peng Shenghai Wang Chen Niu Haining Li Ming Zhang |
| author_sort | Mingyue Ma |
| collection | DOAJ |
| description | Acute carbon monoxide poisoning (ACOP) is a significant contributor to acute poisoning incidents worldwide, with numerous patients suffering from cognitive impairment. Growing evidence indicates that patients with ACOP exhibit both disrupted functional connectivity and corpus callosum (CC) degeneration. Nevertheless, how interhemispheric connectivity is altered in ACOP and how such alterations relate to cognitive deficits remain largely unexplored. In this study, multimodal magnetic resonance imaging was performed on 30 patients with ACOP and 28 healthy controls (HC), and their cognitive functions were evaluated. Group differences in the voxel-mirrored homotopic connectivity (VMHC) index and CC white matter microstructure were analyzed. Furthermore, mediation analysis was conducted to elucidate the interrelationships among CC integrity, interhemispheric connectivity, and cognitive impairment. Compared to HC, patients with ACOP exhibited reduced VMHC values in the middle frontal gyrus, inferior parietal lobule, precentral gyrus, and temporal regions, along with decreased fractional anisotropy values in the subregions of the CC, including the genu, body, and splenium. Partial correlation analyses showed that VMHC in the inferior parietal lobule positively correlated with Glasgow Coma Scale scores. In addition, VMHC in both the inferior parietal lobule and the middle temporal gyrus positively correlated with Montreal Cognitive Assessment-Basic scores. Mediation analysis indicated that changes in interhemispheric connectivity played a crucial role in mediating the effect of CC integrity on cognitive impairment. Together, these findings may offer novel insights into the neurobiological mechanisms underlying ACOP. |
| format | Article |
| id | doaj-art-efc202e7b8164be2aea4e5199bb76bcf |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-efc202e7b8164be2aea4e5199bb76bcf2025-08-20T03:46:34ZengElsevierBrain Research Bulletin1873-27472025-07-0122711137610.1016/j.brainresbull.2025.111376Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoningMingyue Ma0Yu Shang1Xiaoying Lin2Wenxuan Han3Yihao Peng4Shenghai Wang5Chen Niu6Haining Li7Ming Zhang8Department of Medical Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; Department of Radiology, the Affiliated Xi’an Central Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaSchool of Future Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Medical Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Medical Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Medical Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; Department of Medical Imaging, Yan’an People’s Hospital of Shaanxi Province, Yan’an, Shaanxi, ChinaDepartment of PET/CT, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of PET/CT, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Medical Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; Correspondence to: Department of Medical Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, Shaanxi 710061,China.Acute carbon monoxide poisoning (ACOP) is a significant contributor to acute poisoning incidents worldwide, with numerous patients suffering from cognitive impairment. Growing evidence indicates that patients with ACOP exhibit both disrupted functional connectivity and corpus callosum (CC) degeneration. Nevertheless, how interhemispheric connectivity is altered in ACOP and how such alterations relate to cognitive deficits remain largely unexplored. In this study, multimodal magnetic resonance imaging was performed on 30 patients with ACOP and 28 healthy controls (HC), and their cognitive functions were evaluated. Group differences in the voxel-mirrored homotopic connectivity (VMHC) index and CC white matter microstructure were analyzed. Furthermore, mediation analysis was conducted to elucidate the interrelationships among CC integrity, interhemispheric connectivity, and cognitive impairment. Compared to HC, patients with ACOP exhibited reduced VMHC values in the middle frontal gyrus, inferior parietal lobule, precentral gyrus, and temporal regions, along with decreased fractional anisotropy values in the subregions of the CC, including the genu, body, and splenium. Partial correlation analyses showed that VMHC in the inferior parietal lobule positively correlated with Glasgow Coma Scale scores. In addition, VMHC in both the inferior parietal lobule and the middle temporal gyrus positively correlated with Montreal Cognitive Assessment-Basic scores. Mediation analysis indicated that changes in interhemispheric connectivity played a crucial role in mediating the effect of CC integrity on cognitive impairment. Together, these findings may offer novel insights into the neurobiological mechanisms underlying ACOP.http://www.sciencedirect.com/science/article/pii/S0361923025001881Acute carbon monoxide poisoningCognitive impairmentsVoxel-mirrored homotopic connectivityResting-state functional magnetic resonance imagingCorpus callosum |
| spellingShingle | Mingyue Ma Yu Shang Xiaoying Lin Wenxuan Han Yihao Peng Shenghai Wang Chen Niu Haining Li Ming Zhang Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning Brain Research Bulletin Acute carbon monoxide poisoning Cognitive impairments Voxel-mirrored homotopic connectivity Resting-state functional magnetic resonance imaging Corpus callosum |
| title | Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning |
| title_full | Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning |
| title_fullStr | Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning |
| title_full_unstemmed | Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning |
| title_short | Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning |
| title_sort | aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning |
| topic | Acute carbon monoxide poisoning Cognitive impairments Voxel-mirrored homotopic connectivity Resting-state functional magnetic resonance imaging Corpus callosum |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025001881 |
| work_keys_str_mv | AT mingyuema aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning AT yushang aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning AT xiaoyinglin aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning AT wenxuanhan aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning AT yihaopeng aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning AT shenghaiwang aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning AT chenniu aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning AT hainingli aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning AT mingzhang aberrantinterhemisphericrestingstatefunctionalconnectivityandcorpuscallosummicrostructureinacutecarbonmonoxidepoisoning |