Carpaine ameliorates synovial inflammation by promoting p65 degradation and inhibiting the NF-κB signalling pathway

Carpaine ameliorates synovial inflammation by promoting p65 degradation and inhibiting the NF-κB signalling pathway

Aims: Osteoarthritis (OA) is a chronic and debilitating joint disease. Despite its prevalence, especially in ageing and obese populations, effective treatments targeting the molecular mechanisms of OA are limited. This study aimed to investigate the role of carpaine (CP), a major alkaloid from the...

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Bibliographic Details
Main Authors: Hongbo Zhang, Ziyang Li, Zhicheng Zhang, Haobin Li, Zihao Yao, Haiyan Zhang, Chang Zhao, Xiaochun Bai, Chenglong Pan, Daozhang Cai, Chun Zeng
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-04-01
Series:Bone & Joint Research
Subjects:
osteoarthritis
nf-κb signalling
synovitis
synovial inflammation
macrophages
interleukin
cartilage destruction
il-6
rna
cartilage degeneration
quantitative polymerase chain reaction
antibodies
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.144.BJR-2024-0327.R1
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