Boosting AMPs’ Power: From Structural Engineering to Nanotechnology-Based Delivery
Antimicrobial peptides (AMPs) represent a powerful support to conventional antibiotics in addressing the global challenge of antimicrobial resistance (AMR). Their broad-spectrum antimicrobial activity and unique mechanisms of action enable diverse potential applications, including combating multidru...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/14/2979 |
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| author | Oluwasegun Eric Ajayi Rosa Bellavita Lorenzo Emiliano Imbò Sara Palladino Simone Braccia Annarita Falanga Stefania Galdiero |
| author_facet | Oluwasegun Eric Ajayi Rosa Bellavita Lorenzo Emiliano Imbò Sara Palladino Simone Braccia Annarita Falanga Stefania Galdiero |
| author_sort | Oluwasegun Eric Ajayi |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) represent a powerful support to conventional antibiotics in addressing the global challenge of antimicrobial resistance (AMR). Their broad-spectrum antimicrobial activity and unique mechanisms of action enable diverse potential applications, including combating multidrug-resistant pathogens, immune modulation, and cancer therapy. Their clinical implementation is hindered by challenges such as toxicity, instability, and high production costs. Recent advances in AMP design, optimization, and delivery mechanisms such as nanoparticle conjugation and rational engineering have enhanced their efficacy, stability, and specificity. Integrating AMPs into precision medicine and combining them with existing therapies promises to overcome current limitations. With ongoing advancements, AMPs have the potential to redefine infection management and possibly other medical problems. |
| format | Article |
| id | doaj-art-efc0431399804465a3cfb229483d6aed |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-efc0431399804465a3cfb229483d6aed2025-08-20T02:47:14ZengMDPI AGMolecules1420-30492025-07-013014297910.3390/molecules30142979Boosting AMPs’ Power: From Structural Engineering to Nanotechnology-Based DeliveryOluwasegun Eric Ajayi0Rosa Bellavita1Lorenzo Emiliano Imbò2Sara Palladino3Simone Braccia4Annarita Falanga5Stefania Galdiero6INTHERAPI Graduate School, Universite de Bourgogne, 21000 Dijon, FranceDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyDepartment of Agricultural Sciences, University of Naples Federico II, Via Università 100, Portici, 80055 Portici, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyDepartment of Agricultural Sciences, University of Naples Federico II, Via Università 100, Portici, 80055 Portici, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyAntimicrobial peptides (AMPs) represent a powerful support to conventional antibiotics in addressing the global challenge of antimicrobial resistance (AMR). Their broad-spectrum antimicrobial activity and unique mechanisms of action enable diverse potential applications, including combating multidrug-resistant pathogens, immune modulation, and cancer therapy. Their clinical implementation is hindered by challenges such as toxicity, instability, and high production costs. Recent advances in AMP design, optimization, and delivery mechanisms such as nanoparticle conjugation and rational engineering have enhanced their efficacy, stability, and specificity. Integrating AMPs into precision medicine and combining them with existing therapies promises to overcome current limitations. With ongoing advancements, AMPs have the potential to redefine infection management and possibly other medical problems.https://www.mdpi.com/1420-3049/30/14/2979antimicrobial peptidesdrug deliverypeptide strategiesnanoparticle conjugationbiofilms |
| spellingShingle | Oluwasegun Eric Ajayi Rosa Bellavita Lorenzo Emiliano Imbò Sara Palladino Simone Braccia Annarita Falanga Stefania Galdiero Boosting AMPs’ Power: From Structural Engineering to Nanotechnology-Based Delivery Molecules antimicrobial peptides drug delivery peptide strategies nanoparticle conjugation biofilms |
| title | Boosting AMPs’ Power: From Structural Engineering to Nanotechnology-Based Delivery |
| title_full | Boosting AMPs’ Power: From Structural Engineering to Nanotechnology-Based Delivery |
| title_fullStr | Boosting AMPs’ Power: From Structural Engineering to Nanotechnology-Based Delivery |
| title_full_unstemmed | Boosting AMPs’ Power: From Structural Engineering to Nanotechnology-Based Delivery |
| title_short | Boosting AMPs’ Power: From Structural Engineering to Nanotechnology-Based Delivery |
| title_sort | boosting amps power from structural engineering to nanotechnology based delivery |
| topic | antimicrobial peptides drug delivery peptide strategies nanoparticle conjugation biofilms |
| url | https://www.mdpi.com/1420-3049/30/14/2979 |
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