Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors

Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors

Abstract Recombinant adeno-associated viral vectors (rAAV) are a powerful tool for gene delivery but have a limited DNA carrying capacity. Efforts to expand this genetic payload have focused on engineering the vector components, such as dual trans-splicing vectors which double the delivery size by e...

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Bibliographic Details
Main Authors: Anna C. Maurer, Brian Benyamini, Oscar N. Whitney, Vinson B. Fan, Claudia Cattoglio, Djem U. Kissiov, Gina M. Dailey, Xavier Darzacq, Matthew D. Weitzman, Robert Tjian
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56738-5
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