Diabetes Ketoacidosis and Bilateral Cerebral Venous Sinus Thrombosis

Cerebral venous sinus thrombosis (CVST) is a rare condition marked by clot formation in the cerebral veins, often leading to significant neurologic impairment. This case involves a woman in her 60s presenting with altered mental status, slurred speech, and difficulty ambulating. She was diagnosed wi...

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Main Authors: Ashni Dharia, Himsikhar Khataniar, Sahil Sardana, Harmanpreet Bandesha, Patricia Bononi
Format: Article
Language:English
Published: American College of Physicians 2025-07-01
Series:Annals of Internal Medicine: Clinical Cases
Online Access:https://www.acpjournals.org/doi/10.7326/aimcc.2024.1184
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author Ashni Dharia
Himsikhar Khataniar
Sahil Sardana
Harmanpreet Bandesha
Patricia Bononi
author_facet Ashni Dharia
Himsikhar Khataniar
Sahil Sardana
Harmanpreet Bandesha
Patricia Bononi
author_sort Ashni Dharia
collection DOAJ
description Cerebral venous sinus thrombosis (CVST) is a rare condition marked by clot formation in the cerebral veins, often leading to significant neurologic impairment. This case involves a woman in her 60s presenting with altered mental status, slurred speech, and difficulty ambulating. She was diagnosed with diabetic ketoacidosis (DKA) and bilateral CVST with negative hypercoagulable, cardiac, or infectious screenings. Treatment included fluid resuscitation, insulin, and anticoagulation therapy, resulting in improved neurologic symptoms. This case underscores the need for clinicians to consider CVST in DKA patients with neurologic signs because early detection can prevent complications and enhance outcomes.
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series Annals of Internal Medicine: Clinical Cases
spelling doaj-art-efbb548e841c4bb79907ab7616c27d1c2025-08-20T03:32:57ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-07-014710.7326/aimcc.2024.1184Diabetes Ketoacidosis and Bilateral Cerebral Venous Sinus ThrombosisAshni Dharia0Himsikhar Khataniar1Sahil Sardana2Harmanpreet Bandesha3Patricia Bononi41Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania1Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania1Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania2Department of Radiology, Allegheny General Hospital, Pittsburgh, Pennsylvania3Department of Endocrinology, Allegheny General Hospital, Pittsburgh, PennsylvaniaCerebral venous sinus thrombosis (CVST) is a rare condition marked by clot formation in the cerebral veins, often leading to significant neurologic impairment. This case involves a woman in her 60s presenting with altered mental status, slurred speech, and difficulty ambulating. She was diagnosed with diabetic ketoacidosis (DKA) and bilateral CVST with negative hypercoagulable, cardiac, or infectious screenings. Treatment included fluid resuscitation, insulin, and anticoagulation therapy, resulting in improved neurologic symptoms. This case underscores the need for clinicians to consider CVST in DKA patients with neurologic signs because early detection can prevent complications and enhance outcomes.https://www.acpjournals.org/doi/10.7326/aimcc.2024.1184
spellingShingle Ashni Dharia
Himsikhar Khataniar
Sahil Sardana
Harmanpreet Bandesha
Patricia Bononi
Diabetes Ketoacidosis and Bilateral Cerebral Venous Sinus Thrombosis
Annals of Internal Medicine: Clinical Cases
title Diabetes Ketoacidosis and Bilateral Cerebral Venous Sinus Thrombosis
title_full Diabetes Ketoacidosis and Bilateral Cerebral Venous Sinus Thrombosis
title_fullStr Diabetes Ketoacidosis and Bilateral Cerebral Venous Sinus Thrombosis
title_full_unstemmed Diabetes Ketoacidosis and Bilateral Cerebral Venous Sinus Thrombosis
title_short Diabetes Ketoacidosis and Bilateral Cerebral Venous Sinus Thrombosis
title_sort diabetes ketoacidosis and bilateral cerebral venous sinus thrombosis
url https://www.acpjournals.org/doi/10.7326/aimcc.2024.1184
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