Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention
Heart rate (HR) has been proved to be associated with major adverse cardiovascular events (MACE) in Acute coronary syndrome patients. However, the threshold value and clinical significance of time in target of resting heart rate (TTR-HR) remain insufficiently elucidated. Our study aimed to evaluate...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2025-01-01
|
| Series: | Global Heart |
| Subjects: | |
| Online Access: | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1384 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859365966249984 |
|---|---|
| author | Jianmei Zheng Cen Chen Zhongcai Fan Qiang Ye Yi Zhong Jinsong Li Hao Huang Jianping Deng Jinghong Zhao Tinglin Xiong Wenjie Tian Xuemei Zhang |
| author_facet | Jianmei Zheng Cen Chen Zhongcai Fan Qiang Ye Yi Zhong Jinsong Li Hao Huang Jianping Deng Jinghong Zhao Tinglin Xiong Wenjie Tian Xuemei Zhang |
| author_sort | Jianmei Zheng |
| collection | DOAJ |
| description | Heart rate (HR) has been proved to be associated with major adverse cardiovascular events (MACE) in Acute coronary syndrome patients. However, the threshold value and clinical significance of time in target of resting heart rate (TTR-HR) remain insufficiently elucidated. Our study aimed to evaluate the independent association between TTR-HR and cardiovascular outcomes in the follow-up study of ACS. A total of 1455 ACS patients who underwent percutaneous coronary intervention (PCI) and were admitted to 22 hospitals between 2019 and 2022 were enrolled and followed up for 12 months. MACE was defined as a composite of cardiac death, nonfatal recurrent myocardial infarction, ischemic-driven revascularization, and ischemic stroke. The association between TTR-HR and cardiovascular outcomes was assessed using Cox regression model. Compared to patients with TTR-HR 0–50% and >50%–75%, patients with TTR-HR > 75%–100% were older and less alcohol user, less likely to use diuretics and anti-diabetic drugs, these patients had less comorbidities of hyperlipidemia, diabetes, heart failure, and cardiac shock. After 12 months follow up, the incidence of MACE and composite endpoint but not mortality was higher in patients with TTR-HR 0–50% and >50%–75% than those with TTR-HR > 75%–100%. After multivariate adjustment, TTR-HR [hazard ratio = 2.11, 95% CI: 1.19–3.74, p = 0.01] was independently associated with composite endpoint. In summary, our study demonstrates that TTR-HR holds significant prognostic value, with TTR-HR > 75%–100% being independently associated with reduced composite endpoint risk in ACS patients following PCI. These findings emphasize the importance of effective heart rate control in ACS patients following PCI. |
| format | Article |
| id | doaj-art-efba360acca24ed29b53489419ec35d7 |
| institution | Kabale University |
| issn | 2211-8179 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Global Heart |
| spelling | doaj-art-efba360acca24ed29b53489419ec35d72025-02-11T05:32:44ZengUbiquity PressGlobal Heart2211-81792025-01-012013310.5334/gh.13841365Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary InterventionJianmei Zheng0Cen Chen1https://orcid.org/0009-0007-8080-455XZhongcai Fan2Qiang Ye3https://orcid.org/0000-0002-9018-8224Yi Zhong4https://orcid.org/0009-0003-8182-1547Jinsong Li5https://orcid.org/0000-0002-0862-8279Hao Huang6https://orcid.org/0000-0003-1748-1245Jianping Deng7https://orcid.org/0009-0006-1523-002XJinghong Zhao8https://orcid.org/0009-0006-5178-4820Tinglin Xiong9https://orcid.org/0000-0003-0846-4515Wenjie Tian10https://orcid.org/0000-0002-4328-0255Xuemei Zhang11https://orcid.org/0009-0009-5723-029XThe Affiliated Hospital of Southwest Medical University, LuzhouThe First People’s Hospital of Chongqing Liang Jiang New Area, ChongqingThe Affiliated Hospital of Southwest Medical University, LuzhouThe Affiliated Hospital of Southwest Medical University, LuzhouThe Affiliated Hospital of Southwest Medical University, LuzhouSichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, ChengduSichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, ChengduNanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, NanchongNanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, NanchongNanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, NanchongSichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, ChengduThe Affiliated Hospital of Southwest Medical University, LuzhouHeart rate (HR) has been proved to be associated with major adverse cardiovascular events (MACE) in Acute coronary syndrome patients. However, the threshold value and clinical significance of time in target of resting heart rate (TTR-HR) remain insufficiently elucidated. Our study aimed to evaluate the independent association between TTR-HR and cardiovascular outcomes in the follow-up study of ACS. A total of 1455 ACS patients who underwent percutaneous coronary intervention (PCI) and were admitted to 22 hospitals between 2019 and 2022 were enrolled and followed up for 12 months. MACE was defined as a composite of cardiac death, nonfatal recurrent myocardial infarction, ischemic-driven revascularization, and ischemic stroke. The association between TTR-HR and cardiovascular outcomes was assessed using Cox regression model. Compared to patients with TTR-HR 0–50% and >50%–75%, patients with TTR-HR > 75%–100% were older and less alcohol user, less likely to use diuretics and anti-diabetic drugs, these patients had less comorbidities of hyperlipidemia, diabetes, heart failure, and cardiac shock. After 12 months follow up, the incidence of MACE and composite endpoint but not mortality was higher in patients with TTR-HR 0–50% and >50%–75% than those with TTR-HR > 75%–100%. After multivariate adjustment, TTR-HR [hazard ratio = 2.11, 95% CI: 1.19–3.74, p = 0.01] was independently associated with composite endpoint. In summary, our study demonstrates that TTR-HR holds significant prognostic value, with TTR-HR > 75%–100% being independently associated with reduced composite endpoint risk in ACS patients following PCI. These findings emphasize the importance of effective heart rate control in ACS patients following PCI.https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1384acute coronary syndromespercutaneous coronary interventionheart rateclinical outcomes |
| spellingShingle | Jianmei Zheng Cen Chen Zhongcai Fan Qiang Ye Yi Zhong Jinsong Li Hao Huang Jianping Deng Jinghong Zhao Tinglin Xiong Wenjie Tian Xuemei Zhang Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention Global Heart acute coronary syndromes percutaneous coronary intervention heart rate clinical outcomes |
| title | Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention |
| title_full | Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention |
| title_fullStr | Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention |
| title_full_unstemmed | Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention |
| title_short | Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention |
| title_sort | association of time in target range of resting heart rate with adverse clinical outcomes in patients with acute coronary syndromes after percutaneous coronary intervention |
| topic | acute coronary syndromes percutaneous coronary intervention heart rate clinical outcomes |
| url | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1384 |
| work_keys_str_mv | AT jianmeizheng associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT cenchen associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT zhongcaifan associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT qiangye associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT yizhong associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT jinsongli associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT haohuang associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT jianpingdeng associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT jinghongzhao associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT tinglinxiong associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT wenjietian associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention AT xuemeizhang associationoftimeintargetrangeofrestingheartratewithadverseclinicaloutcomesinpatientswithacutecoronarysyndromesafterpercutaneouscoronaryintervention |