The unique role of anosognosia in the clinical progression of Alzheimer’s disease: a disorder-network perspective
Abstract Alzheimer’s disease (AD) encompasses a long continuum from a preclinical phase, characterized by neuropathological alterations albeit normal cognition, to a symptomatic phase, marked by its clinical manifestations. Yet, the neural mechanisms responsible for cognitive decline in AD patients...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-10-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07076-7 |
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| _version_ | 1850201934113275904 |
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| author | Katia Andrade Valentina Pacella |
| author_facet | Katia Andrade Valentina Pacella |
| author_sort | Katia Andrade |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) encompasses a long continuum from a preclinical phase, characterized by neuropathological alterations albeit normal cognition, to a symptomatic phase, marked by its clinical manifestations. Yet, the neural mechanisms responsible for cognitive decline in AD patients remain poorly understood. Here, we posit that anosognosia, emerging from an error-monitoring failure due to early amyloid-β deposits in the posterior cingulate cortex, plays a causal role in the clinical progression of AD by preventing patients from being aware of their deficits and implementing strategies to cope with their difficulties, thus fostering a vicious circle of cognitive decline. |
| format | Article |
| id | doaj-art-efb7b56923c4412582ceb0dfd2298137 |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-efb7b56923c4412582ceb0dfd22981372025-08-20T02:11:54ZengNature PortfolioCommunications Biology2399-36422024-10-017111010.1038/s42003-024-07076-7The unique role of anosognosia in the clinical progression of Alzheimer’s disease: a disorder-network perspectiveKatia Andrade0Valentina Pacella1Institute of Memory and Alzheimer’s Disease (IM2A), Department of Neurology, Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne University, Pitié-Salpêtrière HospitalIUSS Cognitive Neuroscience (ICON) Center, Scuola Universitaria Superiore IUSSAbstract Alzheimer’s disease (AD) encompasses a long continuum from a preclinical phase, characterized by neuropathological alterations albeit normal cognition, to a symptomatic phase, marked by its clinical manifestations. Yet, the neural mechanisms responsible for cognitive decline in AD patients remain poorly understood. Here, we posit that anosognosia, emerging from an error-monitoring failure due to early amyloid-β deposits in the posterior cingulate cortex, plays a causal role in the clinical progression of AD by preventing patients from being aware of their deficits and implementing strategies to cope with their difficulties, thus fostering a vicious circle of cognitive decline.https://doi.org/10.1038/s42003-024-07076-7 |
| spellingShingle | Katia Andrade Valentina Pacella The unique role of anosognosia in the clinical progression of Alzheimer’s disease: a disorder-network perspective Communications Biology |
| title | The unique role of anosognosia in the clinical progression of Alzheimer’s disease: a disorder-network perspective |
| title_full | The unique role of anosognosia in the clinical progression of Alzheimer’s disease: a disorder-network perspective |
| title_fullStr | The unique role of anosognosia in the clinical progression of Alzheimer’s disease: a disorder-network perspective |
| title_full_unstemmed | The unique role of anosognosia in the clinical progression of Alzheimer’s disease: a disorder-network perspective |
| title_short | The unique role of anosognosia in the clinical progression of Alzheimer’s disease: a disorder-network perspective |
| title_sort | unique role of anosognosia in the clinical progression of alzheimer s disease a disorder network perspective |
| url | https://doi.org/10.1038/s42003-024-07076-7 |
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