Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder-A prospective, randomized, single-blinded, sham-controlled trial.
<h4>Background</h4>Frozen shoulder, or adhesive capsulitis, is a debilitating condition characterized by progressive pain and restricted range of motion in the glenohumeral joint. A wide range of interventions has been explored for its management, including conservative physiotherapy app...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0328783 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849228193945354240 |
|---|---|
| author | Gopal Nambi Mshari Alghadier Elturabi Elsayed Ebrahim Mudathir Mohamedahmed Eltayeb Dena Eltabey Sobeh Osama R Aldhafian Shahul Hameed Pakkir Mohamed Naif Nwihadh Alshahrani Faizan Z Kashoo Hariraja Muthusamy Radhakrishnan Unnikrishnan Alaa Jameel A Albarakati |
| author_facet | Gopal Nambi Mshari Alghadier Elturabi Elsayed Ebrahim Mudathir Mohamedahmed Eltayeb Dena Eltabey Sobeh Osama R Aldhafian Shahul Hameed Pakkir Mohamed Naif Nwihadh Alshahrani Faizan Z Kashoo Hariraja Muthusamy Radhakrishnan Unnikrishnan Alaa Jameel A Albarakati |
| author_sort | Gopal Nambi |
| collection | DOAJ |
| description | <h4>Background</h4>Frozen shoulder, or adhesive capsulitis, is a debilitating condition characterized by progressive pain and restricted range of motion in the glenohumeral joint. A wide range of interventions has been explored for its management, including conservative physiotherapy approaches such as thermotherapy, manual therapy, and therapeutic exercises. Pharmacological interventions, including pain medications, and muscle relaxants are commonly employed to alleviate symptoms. Additionally, intra-articular corticosteroid injections have been shown to provide short-term relief. While each modality offers potential benefits, the optimal treatment strategy remains a subject of ongoing investigation.<h4>Purpose</h4>The objective of this study is to investigate the clinical and magnetic resonance image (MRI) changes after lidocaine injection with manual therapy in frozen shoulder.<h4>Study design/ setting</h4>Randomized, single-blinded controlled study conducted at University hospital.<h4>Patient sample</h4>Sixty eligible participants were divided into an active group (n = 30; Lidocaine injection with active manual therapy) and the placebo group (n = 30; Lidocaine injection with placebo manual therapy) 4 sessions per week for 4 weeks.<h4>Outcome measures</h4>The primary outcome was pain intensity, measured with the visual analogue scale and the other outcome measures were range of motion (ROM), functional disability, thickness of corocohumeral ligament (CHL) by MRI, and quality of life which was measured at baseline, after 4 weeks, 8 weeks and at 6 months.<h4>Results</h4>The VAS score at 4 weeks shows an improvement 2.4 (CI 95% 2.08 to 2.71) in the active group than the placebo group. Similar effects have been noted after 8 weeks 3.0 (CI95% 2.68 to 3.31) and at 6 months 2.5 (CI95% 2.18 to 2.81). Similar statistically significant improvements were found in the ROM (abduction & Lateral rotation), functional disability, thickness of CHL ligament, status and quality of life (p = 0.001).<h4>Conclusion</h4>Lidocaine injection with active manual therapy consists of scapula mobilization and posterior capsular stretching was superior to placebo group for improving pain, ROM, functional disability, and quality of life in people with frozen shoulder.<h4>Trial registration</h4>ClinicalTrials.gov CTRI/2020/04/024853. |
| format | Article |
| id | doaj-art-efb3f084dbb146a396faf4153acfdfed |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-efb3f084dbb146a396faf4153acfdfed2025-08-23T05:32:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01208e032878310.1371/journal.pone.0328783Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder-A prospective, randomized, single-blinded, sham-controlled trial.Gopal NambiMshari AlghadierElturabi Elsayed EbrahimMudathir Mohamedahmed EltayebDena Eltabey SobehOsama R AldhafianShahul Hameed Pakkir MohamedNaif Nwihadh AlshahraniFaizan Z KashooHariraja MuthusamyRadhakrishnan UnnikrishnanAlaa Jameel A Albarakati<h4>Background</h4>Frozen shoulder, or adhesive capsulitis, is a debilitating condition characterized by progressive pain and restricted range of motion in the glenohumeral joint. A wide range of interventions has been explored for its management, including conservative physiotherapy approaches such as thermotherapy, manual therapy, and therapeutic exercises. Pharmacological interventions, including pain medications, and muscle relaxants are commonly employed to alleviate symptoms. Additionally, intra-articular corticosteroid injections have been shown to provide short-term relief. While each modality offers potential benefits, the optimal treatment strategy remains a subject of ongoing investigation.<h4>Purpose</h4>The objective of this study is to investigate the clinical and magnetic resonance image (MRI) changes after lidocaine injection with manual therapy in frozen shoulder.<h4>Study design/ setting</h4>Randomized, single-blinded controlled study conducted at University hospital.<h4>Patient sample</h4>Sixty eligible participants were divided into an active group (n = 30; Lidocaine injection with active manual therapy) and the placebo group (n = 30; Lidocaine injection with placebo manual therapy) 4 sessions per week for 4 weeks.<h4>Outcome measures</h4>The primary outcome was pain intensity, measured with the visual analogue scale and the other outcome measures were range of motion (ROM), functional disability, thickness of corocohumeral ligament (CHL) by MRI, and quality of life which was measured at baseline, after 4 weeks, 8 weeks and at 6 months.<h4>Results</h4>The VAS score at 4 weeks shows an improvement 2.4 (CI 95% 2.08 to 2.71) in the active group than the placebo group. Similar effects have been noted after 8 weeks 3.0 (CI95% 2.68 to 3.31) and at 6 months 2.5 (CI95% 2.18 to 2.81). Similar statistically significant improvements were found in the ROM (abduction & Lateral rotation), functional disability, thickness of CHL ligament, status and quality of life (p = 0.001).<h4>Conclusion</h4>Lidocaine injection with active manual therapy consists of scapula mobilization and posterior capsular stretching was superior to placebo group for improving pain, ROM, functional disability, and quality of life in people with frozen shoulder.<h4>Trial registration</h4>ClinicalTrials.gov CTRI/2020/04/024853.https://doi.org/10.1371/journal.pone.0328783 |
| spellingShingle | Gopal Nambi Mshari Alghadier Elturabi Elsayed Ebrahim Mudathir Mohamedahmed Eltayeb Dena Eltabey Sobeh Osama R Aldhafian Shahul Hameed Pakkir Mohamed Naif Nwihadh Alshahrani Faizan Z Kashoo Hariraja Muthusamy Radhakrishnan Unnikrishnan Alaa Jameel A Albarakati Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder-A prospective, randomized, single-blinded, sham-controlled trial. PLoS ONE |
| title | Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder-A prospective, randomized, single-blinded, sham-controlled trial. |
| title_full | Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder-A prospective, randomized, single-blinded, sham-controlled trial. |
| title_fullStr | Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder-A prospective, randomized, single-blinded, sham-controlled trial. |
| title_full_unstemmed | Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder-A prospective, randomized, single-blinded, sham-controlled trial. |
| title_short | Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder-A prospective, randomized, single-blinded, sham-controlled trial. |
| title_sort | efficacy of mri and clinical findings of lidocaine injection combined with manual therapy in frozen shoulder a prospective randomized single blinded sham controlled trial |
| url | https://doi.org/10.1371/journal.pone.0328783 |
| work_keys_str_mv | AT gopalnambi efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT msharialghadier efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT elturabielsayedebrahim efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT mudathirmohamedahmedeltayeb efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT denaeltabeysobeh efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT osamaraldhafian efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT shahulhameedpakkirmohamed efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT naifnwihadhalshahrani efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT faizanzkashoo efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT harirajamuthusamy efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT radhakrishnanunnikrishnan efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial AT alaajameelaalbarakati efficacyofmriandclinicalfindingsoflidocaineinjectioncombinedwithmanualtherapyinfrozenshoulderaprospectiverandomizedsingleblindedshamcontrolledtrial |