Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci ach...
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Public Library of Science (PLoS)
2011-04-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002033&type=printable |
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| author | Marilyn C Cornelis Keri L Monda Kai Yu Nina Paynter Elizabeth M Azzato Siiri N Bennett Sonja I Berndt Eric Boerwinkle Stephen Chanock Nilanjan Chatterjee David Couper Gary Curhan Gerardo Heiss Frank B Hu David J Hunter Kevin Jacobs Majken K Jensen Peter Kraft Maria Teresa Landi Jennifer A Nettleton Mark P Purdue Preetha Rajaraman Eric B Rimm Lynda M Rose Nathaniel Rothman Debra Silverman Rachael Stolzenberg-Solomon Amy Subar Meredith Yeager Daniel I Chasman Rob M van Dam Neil E Caporaso |
| author_facet | Marilyn C Cornelis Keri L Monda Kai Yu Nina Paynter Elizabeth M Azzato Siiri N Bennett Sonja I Berndt Eric Boerwinkle Stephen Chanock Nilanjan Chatterjee David Couper Gary Curhan Gerardo Heiss Frank B Hu David J Hunter Kevin Jacobs Majken K Jensen Peter Kraft Maria Teresa Landi Jennifer A Nettleton Mark P Purdue Preetha Rajaraman Eric B Rimm Lynda M Rose Nathaniel Rothman Debra Silverman Rachael Stolzenberg-Solomon Amy Subar Meredith Yeager Daniel I Chasman Rob M van Dam Neil E Caporaso |
| author_sort | Marilyn C Cornelis |
| collection | DOAJ |
| description | We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2. |
| format | Article |
| id | doaj-art-efae535c6ce54d40ad11752fdd73c8ee |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2011-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-efae535c6ce54d40ad11752fdd73c8ee2025-08-20T02:33:56ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042011-04-0174e100203310.1371/journal.pgen.1002033Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.Marilyn C CornelisKeri L MondaKai YuNina PaynterElizabeth M AzzatoSiiri N BennettSonja I BerndtEric BoerwinkleStephen ChanockNilanjan ChatterjeeDavid CouperGary CurhanGerardo HeissFrank B HuDavid J HunterKevin JacobsMajken K JensenPeter KraftMaria Teresa LandiJennifer A NettletonMark P PurduePreetha RajaramanEric B RimmLynda M RoseNathaniel RothmanDebra SilvermanRachael Stolzenberg-SolomonAmy SubarMeredith YeagerDaniel I ChasmanRob M van DamNeil E CaporasoWe report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002033&type=printable |
| spellingShingle | Marilyn C Cornelis Keri L Monda Kai Yu Nina Paynter Elizabeth M Azzato Siiri N Bennett Sonja I Berndt Eric Boerwinkle Stephen Chanock Nilanjan Chatterjee David Couper Gary Curhan Gerardo Heiss Frank B Hu David J Hunter Kevin Jacobs Majken K Jensen Peter Kraft Maria Teresa Landi Jennifer A Nettleton Mark P Purdue Preetha Rajaraman Eric B Rimm Lynda M Rose Nathaniel Rothman Debra Silverman Rachael Stolzenberg-Solomon Amy Subar Meredith Yeager Daniel I Chasman Rob M van Dam Neil E Caporaso Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genetics |
| title | Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. |
| title_full | Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. |
| title_fullStr | Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. |
| title_full_unstemmed | Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. |
| title_short | Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. |
| title_sort | genome wide meta analysis identifies regions on 7p21 ahr and 15q24 cyp1a2 as determinants of habitual caffeine consumption |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002033&type=printable |
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