Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study
Conclusion: Although serum P16ink4A and FOXP3 concentrations showed moderate accuracy, their combination was more specific than sensitive. This combination has a high potential to be applied for diagnosis rather than screening for cervical lesions, at least in the Ugandan population. Combinations of...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/ancp/1931921 |
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| author | Frank Ssedyabane Nixon Niyonzima Joseph Ngonzi Josephine Nambi Najjuma Alexcer Namuli Christopher Okeny Doreen Nuwashaba Abraham Birungi Rogers Kajabwangu Thomas C. Randall Cesar M. Castro Hakho Lee Deusdedit Tusubira |
| author_facet | Frank Ssedyabane Nixon Niyonzima Joseph Ngonzi Josephine Nambi Najjuma Alexcer Namuli Christopher Okeny Doreen Nuwashaba Abraham Birungi Rogers Kajabwangu Thomas C. Randall Cesar M. Castro Hakho Lee Deusdedit Tusubira |
| author_sort | Frank Ssedyabane |
| collection | DOAJ |
| description | Conclusion: Although serum P16ink4A and FOXP3 concentrations showed moderate accuracy, their combination was more specific than sensitive. This combination has a high potential to be applied for diagnosis rather than screening for cervical lesions, at least in the Ugandan population. Combinations of P16ink4A and FOXP3 with other biomarkers could improve diagnostic accuracies. Additionally, studies could be conducted to assess the performance of these biomarkers in the detection of cervical lesions in specific populations, say Human Immunodeficiency Virus (HIV)-positive and HIV-negative populations. |
| format | Article |
| id | doaj-art-efac0fa3e4074fff9068e342b4e7c22a |
| institution | OA Journals |
| issn | 2210-7185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-efac0fa3e4074fff9068e342b4e7c22a2025-08-20T02:24:58ZengWileyAnalytical Cellular Pathology2210-71852025-01-01202510.1155/ancp/1931921Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control StudyFrank Ssedyabane0Nixon Niyonzima1Joseph Ngonzi2Josephine Nambi Najjuma3Alexcer Namuli4Christopher Okeny5Doreen Nuwashaba6Abraham Birungi7Rogers Kajabwangu8Thomas C. Randall9Cesar M. Castro10Hakho Lee11Deusdedit Tusubira12Department of Medical Laboratory ScienceDepartment of Medical Laboratory ScienceDepartment of Obstetrics and GynecologyDepartment of NursingDepartment of Obstetrics and GynecologyDepartment of Medical Laboratory ScienceDepartment of Medical Laboratory ScienceDepartment of PathologyDepartment of Obstetrics and GynecologyDepartment of Global Health and Social MedicineDepartment of NursingCentre for Systems BiologyDepartment of BiochemistryConclusion: Although serum P16ink4A and FOXP3 concentrations showed moderate accuracy, their combination was more specific than sensitive. This combination has a high potential to be applied for diagnosis rather than screening for cervical lesions, at least in the Ugandan population. Combinations of P16ink4A and FOXP3 with other biomarkers could improve diagnostic accuracies. Additionally, studies could be conducted to assess the performance of these biomarkers in the detection of cervical lesions in specific populations, say Human Immunodeficiency Virus (HIV)-positive and HIV-negative populations.http://dx.doi.org/10.1155/ancp/1931921 |
| spellingShingle | Frank Ssedyabane Nixon Niyonzima Joseph Ngonzi Josephine Nambi Najjuma Alexcer Namuli Christopher Okeny Doreen Nuwashaba Abraham Birungi Rogers Kajabwangu Thomas C. Randall Cesar M. Castro Hakho Lee Deusdedit Tusubira Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study Analytical Cellular Pathology |
| title | Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study |
| title_full | Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study |
| title_fullStr | Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study |
| title_full_unstemmed | Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study |
| title_short | Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study |
| title_sort | diagnostic accuracy of serum p16ink4a and fox p3 concentrations for detection of cervical lesions among women attending a cervical cancer clinic in western uganda a case control study |
| url | http://dx.doi.org/10.1155/ancp/1931921 |
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