Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort study
Abstract Purpose The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery. Methods A total of 202 TNBC...
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Springer
2024-12-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-024-06069-7 |
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| author | Xin Liu Kaihua Zhao Ziyan Zhang Meiyan Liu Hongwu Chu Xiao Zou |
| author_facet | Xin Liu Kaihua Zhao Ziyan Zhang Meiyan Liu Hongwu Chu Xiao Zou |
| author_sort | Xin Liu |
| collection | DOAJ |
| description | Abstract Purpose The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery. Methods A total of 202 TNBC patients treated at Qingdao Central Hospital from January 2010 to December 2019 were included, comprising 71 HER2-low and 131 HER2-zero patients. Propensity score matching (PSM) was applied to minimize differences between the cohorts. Results HER2-low TNBC patients had lower histological grade, lower Ki-67 expression levels, and a higher prevalence of hypertension compared to HER2-zero TNBC patients. Before and after PSM, the HER2-low group consistently exhibited a lower recurrence rate and longer RFS compared to HER2-zero TNBC patients. HER2-low status was validated as an independent low-risk factor for RFS both pre-PSM (HR 0.354, 95% CI 0.178–0.706, p = 0.003) and post-PSM (HR 0.405, 95% CI 0.185–0.886, p = 0.024). No statistically significant differences in mortality rate and OS were observed, both before and after PSM. Conclusions HER2-low and HER2-zero TNBC patients show significant clinicopathological differences. Compared to HER2-zero, HER2-low status is linked to better long-term prognosis and serves as an independent low-risk factor for RFS in TNBC patients. |
| format | Article |
| id | doaj-art-efa9f251f2dd4070883185f2554f0eb1 |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
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| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-efa9f251f2dd4070883185f2554f0eb12025-02-09T12:10:19ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352024-12-01151111310.1007/s00432-024-06069-7Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort studyXin Liu0Kaihua Zhao1Ziyan Zhang2Meiyan Liu3Hongwu Chu4Xiao Zou5Qingdao Medical College, Qingdao UniversityDepartment of Breast Surgery, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)Department of Breast Surgery, Women and Children’s Hospital, Qingdao UniversityQingdao Medical College, Qingdao UniversityGuangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen UniversityDepartment of Breast Surgery, Xiangdong Hospital Affiliated to Hunan Normal UniversityAbstract Purpose The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery. Methods A total of 202 TNBC patients treated at Qingdao Central Hospital from January 2010 to December 2019 were included, comprising 71 HER2-low and 131 HER2-zero patients. Propensity score matching (PSM) was applied to minimize differences between the cohorts. Results HER2-low TNBC patients had lower histological grade, lower Ki-67 expression levels, and a higher prevalence of hypertension compared to HER2-zero TNBC patients. Before and after PSM, the HER2-low group consistently exhibited a lower recurrence rate and longer RFS compared to HER2-zero TNBC patients. HER2-low status was validated as an independent low-risk factor for RFS both pre-PSM (HR 0.354, 95% CI 0.178–0.706, p = 0.003) and post-PSM (HR 0.405, 95% CI 0.185–0.886, p = 0.024). No statistically significant differences in mortality rate and OS were observed, both before and after PSM. Conclusions HER2-low and HER2-zero TNBC patients show significant clinicopathological differences. Compared to HER2-zero, HER2-low status is linked to better long-term prognosis and serves as an independent low-risk factor for RFS in TNBC patients.https://doi.org/10.1007/s00432-024-06069-7Triple-negative breast cancerHER2-LowClinicopathological characteristicsLong-term prognosis |
| spellingShingle | Xin Liu Kaihua Zhao Ziyan Zhang Meiyan Liu Hongwu Chu Xiao Zou Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort study Journal of Cancer Research and Clinical Oncology Triple-negative breast cancer HER2-Low Clinicopathological characteristics Long-term prognosis |
| title | Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort study |
| title_full | Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort study |
| title_fullStr | Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort study |
| title_full_unstemmed | Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort study |
| title_short | Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort study |
| title_sort | clinicopathological characteristics and long term prognosis of triple negative breast cancer patients with her2 low expression a retrospective propensity score matched cohort study |
| topic | Triple-negative breast cancer HER2-Low Clinicopathological characteristics Long-term prognosis |
| url | https://doi.org/10.1007/s00432-024-06069-7 |
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